thrombopoietin


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thrombopoietin

 [throm″bo-poi´ĕ-tin]
a colony-stimulating factor that is the humoral regulator of the production of platelets.

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin), [MIM*600044]
A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
[thrombo- + G. poiētēs, maker, + in]

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin)
A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
Synonym(s): megakaryocyte growth and development factor, megapoietin.
[thrombo- + G. poiētēs, maker, + in]

thrombopoietin

A hormone responsible for the growth of colonies of megakaryocytes and the production of platelets. The existence of thrombopoietin has been suspected for 30 years but was realized only in 1994. In 1997 the results of a trial of polyethylene-conjugated genetically-engineered (recombinant) thrombopoietin-described as recombinant human megakatyocyte growth and development factor (PEGrHuMGDF)-was published. It was found to have a powerful stimulatory effect on PLATELET production. Thrombopoietin is the ligand for the cytokine receptor Mpl.

thrombopoietin

an α2-globulin, a hormone involved in the differentiation and maturation of platelets but thought to be responsible for regulating the supply of platelets.
References in periodicals archive ?
At present, thrombopoietin agonist has orphan drug status as a third-line agent in the treatment of patients with chronic immune thrombocytopenia.
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.
Eltrombopag: a novel oral thrombopoietin receptor agonist.
Reactive thrombocytosis can either be transient or sustained and is driven by elevated endogenous concentrations of thrombopoietin, interleukin-6 and other cytokines and catecholamines in situations of stress, inflammation or infection (2).
Knocking-in of the human thrombopoietin gene on beta-casein locus in bovine fibroblasts.
Circadian variations do not have a major impact on serum levels of soluble (S) L-selectin (CD63L), S-intercellular adhesion molecule 1 (sICAM-1/CD54) and thrombopoietin in healthy individuals.
MPL is the receptor for thrombopoietin and interacts with JAK2.
The recombinant human stem cell factor (SCF), Flt-3 ligand (FL), thrombopoietin (TPO), interleukin-3 (IL-3), StemSpan Medium, MethoCult GF+ H4435, and MyeloCult H5100 were all from Stem Cell Technologies (Vancouver, BC, Canada).
The antibody inhibits thrombopoietin, a hormone that spurs cells in the bone marrow to make platelets.
The deal made AkaRx a wholly owned subsidiary of Eisai, which gained the exclusive worldwide rights to develop, market and manufacture AkaRx's AKR-501, an investigational thrombopoietin receptor agonist that, based on preclinical studies, increases platelet production by stimulating megakaryocytic proliferation and differentiation.
For example, Amgen researchers coordinated the development of Thrombopoietin (TPO) with a broad range of alliances and patents, which included Novo Nordisk (Denmark), Kirin (Japan) and Enzon (protein manufacturing technology).