Reticulated platelets in the evaluation of thrombopoietic
Currently, romiplostim is the only thrombopoietic
treatment for adult chronic ITP for which there is three years of follow-up data," said Professor Adrian Newland, Department of Haematology, The Royal London Hospital, Whitechapel, London, UK.
Cells and the Bone Marrow Vascular Niche by H.
aTyr's lead program, scheduled for a pre-IND meeting at the FDA in September, is a novel protein therapeutic, ATYR0030, with thrombopoietic
activity that is initially being developed to treat thrombocytopenia in patients with myelodyspastic syndromes (MDS).
Currently, Nplate is the only thrombopoietic
ITP treatment for which there are over two years of follow-up data," said James Bussel, M.
The invention enables simulating the thrombopoietic
process in virtual patients where different therapies are applied.
These are the first clinical results on AKR-501 that show it may be a safe thrombopoietic
agent that may lessen or eliminate the need for platelet transfusions, benefiting patient health, and, possibly, lowering health care costs.
An Open-Label, Unit Dose-Finding Study Evaluating the Safety and Platelet Response of Novel Thrombopoietic
Protein (AMG531) in Thrombocytopenic Adult Patients with Immune Thrombocytopenic Purpura (ITP) [Abstract 2058]
In addition to MYLOTARG(R) (gemtuzumab ozogamicin for Injection), the company manufactures Neumega(R) (oprelvekin), a thrombopoietic
growth factor for preventing severely lowered platelet counts and the corresponding need for platelet transfusions following chemotherapy.
Today, in the absence of an approved thrombopoietic
factor, when a
Based on an evaluation of the first 12 patients enrolled in the study, Gordon and his associates concluded that Neumega rhIL-11 has thrombopoietic
activity, or the ability to increase platelet production, at all doses studied.