Management of CIT includes dose reduction and/or delay in initiation of further cycles of chemotherapeutic regime, platelet transfusion, and use of thrombopoietic
New insights into the thrombopoietic
status of patients on dialysis through the evaluation of megakaryocytopoiesis in bone marrow and of endogenous thrombopoietin levels.
a) Increased platelet destruction Nonimmunologic Decreased Immunologic processes processes platelet production Autoimmune Microangiopathies Megakaryocyte Idiopathic DIC, (b) TTC, HUS hypoplasia Secondary Ineffective (infections, Platelet damage thrombopoiesis pregnancy, drugs) Hereditary Alloimmune Miscellaneous Neonatal Infection, massive Disorders of Posttransfusion blood transfusion thrombopoietic
control (a) Modified from Parker Levine (7).
In summary, IPF provides an automated, direct cellular measurement of thrombopoietic
activity in bone marrow.
Hsu HC, Tsai WH, Jiang ML, et al: Circulating levels of thrombopoietic
and inflammatory cytokines in patients with clonal and reactive thrombocytosis.
Reticulated platelets in the evaluation of thrombopoietic
Currently, romiplostim is the only thrombopoietic
treatment for adult chronic ITP for which there is three years of follow-up data," said Professor Adrian Newland, Department of Haematology, The Royal London Hospital, Whitechapel, London, UK.
Conversely, if the MPV is low in spite of the decreased platelet count, this indicates a more advanced or aggressive case of MDS, where the bone marrow is completely unable to respond to the thrombopoietic
Cells and the Bone Marrow Vascular Niche by H.
Currently, Nplate is the only thrombopoietic
ITP treatment for which there are over two years of follow-up data," said James Bussel, M.
The invention enables simulating the thrombopoietic
process in virtual patients where different therapies are applied.