Soluble
thrombomodulin, plasminogen activator Type 1 and CRP increase, as well as complement activation, are detected in ES.
Jaradat, "
Thrombomodulin gene proximal promoter polymorphisms in premature acute coronary syndrome patients in Bahrain," Blood Coagulation & Fibrinolysis, vol.
ANOVA revealed highly significant difference of mean among groups and between groups in IL-6, TNF-[alpha], and
thrombomodulin (P<0.01).TNF-[alpha] showed a strong and positive relationship with insulin and insulin resistance in all the three groups.
Circulating
thrombomodulin levels in familial Mediterranean fever.
Hence, this study was designed to investigate the correlation of ABO polymorphism and
thrombomodulin polymorphism -33G>A with the incidence of acute myocardial infarction in Javanese men.
Deyashiki et al., "Structure and expression of human
thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation," European Molecular Biology Organization, vol.
In addition, elevated soluble plasma levels of several EC-derived proteins suggestive of more severe EC injury, including angiopoetin-2,
thrombomodulin, and vWF in ARDS patients, are associated with higher mortality [57-60].
Wu et al., "
Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kappaB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis," Diabetologia, vol.
In the serum and plasma of patients with thalassemia, in vitro studies showed that there are elevated levels of endothelial adhesion proteins (intercellular adhesion molecule-1 [ICAM-1], E-selectin [ELAM-1], vascular cell adhesion molecule-1 [VCAM-1], von Willebrand factor [VWF], and
thrombomodulin) [14, 15].
The inhibitor is slowly activated by thrombin, but this activity of thrombin is three orders of magnitude higher in the presence of
thrombomodulin. The activated form (TAFIa) is a plasma carboxypeptidase B and has a short half-life of about 10 min under physiologic conditions.
For example,
thrombomodulin undergoes renal excretion.
This leads to the formation of an advanced plaque that has a low
thrombomodulin concentration, allowing thrombin to augment the inflammatory stimuli [25].
