thrombomodulin


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throm·bo·mod·u·lin

(throm'bō-mod'yū-lin), [MIM*188040]
A glycoprotein present in the plasma membrane of endothelial cells that binds thrombin; participates in an additional regulatory mechanism in coagulation.
[thrombo- + modulate + -in]

thrombomodulin

(thrŏm″bō-mō′dū-lĭn)
A protein released by the vascular endothelium. Acting in concert with other factors, it helps to prevent formation of intravascular thrombi.

thrombomodulin

A receptor on ENDOTHELIUM that binds thrombin, inhibiting it clot-forming ability and causing it to activate protein C.
References in periodicals archive ?
Soluble thrombomodulin, plasminogen activator Type 1 and CRP increase, as well as complement activation, are detected in ES.
Jaradat, "Thrombomodulin gene proximal promoter polymorphisms in premature acute coronary syndrome patients in Bahrain," Blood Coagulation & Fibrinolysis, vol.
ANOVA revealed highly significant difference of mean among groups and between groups in IL-6, TNF-[alpha], and thrombomodulin (P<0.01).TNF-[alpha] showed a strong and positive relationship with insulin and insulin resistance in all the three groups.
Hence, this study was designed to investigate the correlation of ABO polymorphism and thrombomodulin polymorphism -33G>A with the incidence of acute myocardial infarction in Javanese men.
Deyashiki et al., "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation," European Molecular Biology Organization, vol.
In addition, elevated soluble plasma levels of several EC-derived proteins suggestive of more severe EC injury, including angiopoetin-2, thrombomodulin, and vWF in ARDS patients, are associated with higher mortality [57-60].
Wu et al., "Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kappaB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis," Diabetologia, vol.
In the serum and plasma of patients with thalassemia, in vitro studies showed that there are elevated levels of endothelial adhesion proteins (intercellular adhesion molecule-1 [ICAM-1], E-selectin [ELAM-1], vascular cell adhesion molecule-1 [VCAM-1], von Willebrand factor [VWF], and thrombomodulin) [14, 15].
The inhibitor is slowly activated by thrombin, but this activity of thrombin is three orders of magnitude higher in the presence of thrombomodulin. The activated form (TAFIa) is a plasma carboxypeptidase B and has a short half-life of about 10 min under physiologic conditions.
This leads to the formation of an advanced plaque that has a low thrombomodulin concentration, allowing thrombin to augment the inflammatory stimuli [25].