thrombolytic agent


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Related to thrombolytic agent: Clot busting

thrombolytic agent

Clot-dissolving drug, thrombolytic An agent–eg, tPA, streptokinase, that effects thrombolysis and restores vascular patency–eg, in managing acute MIs. See Thrombolytic therapy, tPA.

thrombolytic agent

Any drug that degrades blood clots. Examples include streptokinase, tenecteplase, tissue plasminogen activator, and urokinase. Such drugs are used to treat the abnormal blood clotting that occurs in heart attacks, some strokes, and pulmonary emboli. They are informally called “clot busters.”

CAUTION!

Thrombolytic drugs should not be given to patients with active bleeding, a history of surgery or major trauma within the preceding two weeks, a brain tumor, or other known risks for intracerebral hemorrhage.
See also: agent
References in periodicals archive ?
Thrombolytic agents belong to a family of drugs called plasminogen activators.
Both systems may be used in combination with thrombolytic agents (Baker et al.
These plasminogen activator type thrombolytic agents may require a prolonged infusion of 24 to 36 hours in patients with leg attack.
About four percent of those patients hospitalized with a heart attack and treated with thrombolytic agents, or clot-busters, will suffer a second heart attack event, or re-infarction, during the initial hospital stay.
However, the amount of the PAI-1 increase did not depend on the thrombolytic agent used, because PAI-1 maximum concentrations did not differ between groups.
The same catheter emits a thrombolytic agent in a continuous infusion through a separate channel.
Additional laboratory evaluation revealed peripheral eosinophilia, which was evident the day after thrombolytic agents were given and persisted until initiation of hemodialysis.
Some investigators have suggested a future stroke treatment "cocktail" that would combine a neuroprotective and a thrombolytic agent.
Differences in clot lysis among patients demonstrated in vitro with three thrombolytic agents (tissue-type plasminogen activator, streptokinase and urokinase).
He said, "To date, the thrombolytic agent tPA is the only effective drug for acute ischemic stroke; however, only about 2 percent of ischemic stroke patients benefit from this treatment due to its limited therapeutic window.
THR-100 is a thrombolytic agent developed for the treatment of acute myocardial infarction (AMI or heart attack) and other vascular diseases, based on its ability to dissolve blood clots.
Tenecteplase is a recently developed reengineered isomer of tissue plasminogen activator that possesses many properties of the ideal cardiac arrest thrombolytic agent.