thrombolytic agent


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Related to thrombolytic agent: Clot busting

thrombolytic agent

Clot-dissolving drug, thrombolytic An agent–eg, tPA, streptokinase, that effects thrombolysis and restores vascular patency–eg, in managing acute MIs. See Thrombolytic therapy, tPA.

thrombolytic agent

Any drug that degrades blood clots. Examples include streptokinase, tenecteplase, tissue plasminogen activator, and urokinase. Such drugs are used to treat the abnormal blood clotting that occurs in heart attacks, some strokes, and pulmonary emboli. They are informally called “clot busters.”

CAUTION!

Thrombolytic drugs should not be given to patients with active bleeding, a history of surgery or major trauma within the preceding two weeks, a brain tumor, or other known risks for intracerebral hemorrhage.
See also: agent
References in periodicals archive ?
Similar to these two large studies of comparing the efficacy of thrombolytics in patients of AMI, reported that there were no significant differences in 30-35 days mortality with three thrombolytic agents, i.
Although the current availability of new generation thrombolytic agent rt-PA, urokinase remained the dominant agent for its general acceptance and low price.
If bleeding cannot be controlled, stop infusion of thrombolytic agent and inform the health care provider immediately.
No controlled trials have compared the different thrombolytic agents.
In addition, among up-to-date thrombolytic agents approved by health authorities only intravenous recombinant tissue plasminogen activator (rt-PA) is used as a systemic one.
We believe the routine use of a thrombolytic agent on clotted blood and bone marrow specimens should become standard for all cytogenetics laboratories.
Acute aortic thromboembolism has been treated either by conservative methods such as supportive care and antithrombotics or by surgical thrombolectomy or administration of thrombolytic agents.
The thrombolytic agent is administered via the multiple side-hole catheter using a starting dose of 10 mg rtPA dissolved in 100 ml of a heparin saline solution injected over half an hour using a 'pulse spray technique'.
Fibrinolytic or thrombolytic agents convert plasminogen to plasmin, lyse the clot by breaking down the fibrin contained in a clot.
Based on my and the company's significant experience in the field of thrombolytic agents, I am optimistic that microplasmin could represent a major advance in the treatment of this very important disease.
However, the hospitals could not agree on which type of thrombolytic agent to use.