thrombolytic agent


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Related to thrombolytic agent: Clot busting

thrombolytic agent

Clot-dissolving drug, thrombolytic An agent–eg, tPA, streptokinase, that effects thrombolysis and restores vascular patency–eg, in managing acute MIs. See Thrombolytic therapy, tPA.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

thrombolytic agent

Any drug that degrades blood clots. Examples include streptokinase, tenecteplase, tissue plasminogen activator, and urokinase. Such drugs are used to treat the abnormal blood clotting that occurs in heart attacks, some strokes, and pulmonary emboli. They are informally called “clot busters.”

CAUTION!

Thrombolytic drugs should not be given to patients with active bleeding, a history of surgery or major trauma within the preceding two weeks, a brain tumor, or other known risks for intracerebral hemorrhage.
See also: agent
Medical Dictionary, © 2009 Farlex and Partners
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In the present study, thrombolytic agents were especially administered to subjects with higher PAP values for the rapid resolution of clots.
Safety and Effectiveness of Thrombolytic Therapy Compared with Standard Anticoagulation in Subjects with Submassive Pulmonary Embolism
It is used clinically as an intravenous thrombolytic agent for the treatment of acute myocardial infarction (MI) by activation of plasminogen indirectly in circulation.
Enhanced Production of Streptokinase by UV- and Ethidium Bromide-Treated Streptococus equisimilis Mutant
Similar to these two large studies of comparing the efficacy of thrombolytics in patients of AMI, reported that there were no significant differences in 30-35 days mortality with three thrombolytic agents, i.e.
Effectiveness and comparison of reteplase versus streptokinase thrombolytic agents in the patients of acute myocardial infarction
If bleeding cannot be controlled, stop infusion of thrombolytic agent and inform the health care provider immediately.
Circulation savers: thrombolytic therapy
There is, therefore, an urgent need for an effective but affordable alternative thrombolytic agent like streptokinase that can be offered to patients across the country.
THROMBOLYSIS IN THE TREATMENT OF ACUTE STROKE: IS THERE A ROLE FOR STREPTOKINASE WHEN TISSUE PLASMINOGEN ACTIVATOR IS NOT AVAILABLE?
Inter-arterial thrombolytic therapy with streptokinase as a thrombolytic agent is an efficient and comparatively safe method for recanalization of occluded vessel in ischemic stroke patients;
Efficacy and safety of intra-arterial thrombolytic therapy for ischemic stroke
We believe the routine use of a thrombolytic agent on clotted blood and bone marrow specimens should become standard for all cytogenetics laboratories.
Application of thrombolytic drugs on clotted blood and bone marrow specimens to generate usable cells for cytogenetic analyses
No thrombolytic agent is currently on the market that has been FDA-approved in HD catheter management.
A practical review of the kidney dialysis outcomes quality initiative (KDOQI) guidelines for hemodialysis catheters and their potential impact on patient care
(It is seen in a small percentage of cats with hypertrophic cardiomyopathy.) Acute aortic thromboembolism has been treated either by conservative methods such as supportive care and antithrombotics or by surgical thrombolectomy or administration of thrombolytic agents.
Blood clots in cats with heart disease
The only drug approved by the FDA for treatment of acute ischemic stroke is a thrombolytic agent called tissue plaminogen activator (Tpa).
From the editor's desk
None of the other factors studied--systolic blood pressure, admitting glucose levels, admitting platelet levels, site of occlusion thrombolytic agent, and age--was significant in predicting rapid recovery.
Intra-arterial therapy offers huge gains for some
Frans Van de Werf, professor of cardiology at the University of Leuven (Belgium), speculated that another possible explanation for TROICA's failure might be that the blood flow generated during prolonged CPR was insufficient to bring the thrombolytic agent to the thrombus.
Thrombolysis is unexpected flop in out-of-hospital cardiac arrest study

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