Despite increasing evidence that LOX-1, a cell-surface receptor for oxLDL, is implicated in
thrombogenesis and atherogenesis, its involvement in the regulation of TF expression in macrophages remains unclear.
Therefore, overall effect of simvastatin beyond lowering cholesterol includes improving endothelial function, modulating
thrombogenesis, attenuating inflammatory, and oxidative stress damage, and facilitating angiogenesis [17].
Vascular Gas6 contributes to
thrombogenesis and promotes tissue factor upregulation after vessel injury in mice.
Differential effects of alpha- and gamma-tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial
thrombogenesis. J Am Coll Cardiol.
Increased von Willebrand factor in the endocardium asa local predisposing factor for
thrombogenesis in overloaded human atrial appendage.
Platelets also have a very important role in hemostasis and
thrombogenesis. Platelet is a catalyzing coagulation reaction agent, which leads to the formation of fibrin, but does not react negatively with other blood cells [8].
Moeslinger, "ATP-sensitive potassium channels expressed by human monocytes play a role in stasis-induced
thrombogenesis via tissue factor pathway," Life Sciences, vol.
Lip, "Atrial fibrillation, arrhythmia burden and
thrombogenesis," International Journal of Cardiology, vol.
5-HT, induced by impaired vascular endothelial cells, is involved in the pathological process of platelet aggregation [45],
thrombogenesis [65], contraction of carotid arteries [66], and arteriogenesis [67] in DM-induced vascular complications through 5-H[T.sub.2A]R.
Tumor cells express tissue factors that activate the clotting cascade, tumor procoagulants, fibrinolytic proteins and receptors for these factors, promoting interactions between the tumor cells, platelets and endothelial cells via cytokines, tumor antigens, and their immune complexes to facilitate
thrombogenesis [4].
However, evidence has shown that platelet microparticles (PMP) have a major role in
thrombogenesis in ITP.
It is possible that treating eosinophilia removed the driving factor of
thrombogenesis and subsequently led to rapid thrombolysis.
