Does menopause affect
thrombocytopoiesis and platelet activation?
Cytologic analysis of bone marrow showed normal granulocytopoiesis, while erythropoiesis and
thrombocytopoiesis were absent.
The number of large immature platelets in patients with ACS is caused by an increased bone marrow activity during the process known as
thrombocytopoiesis.
Does menopause affect
thrombocytopoiesis and platelet activation Przegel Lek 2006; 63:1291-3.
[7] Megaloblastic anemia was found in 1.9% patients due to vitamin B12 and folic acid deficiency as a result of ineffective
thrombocytopoiesis. In patients with HIV (1.4%), thrombocytopenia may be related directly to HIV infection, adverse effect of drug therapy, or secondary malignancy or myelodysplasia.
Parameter Polycythemia vera Anoxemic or secondary polycythemia Fundamental Hyperplastic Anoxemia situation panmyelopathy Etiology Unknown Anoxemia (altitude, cardiac, pulmonary) Bone marrow Excessive Excessive erythropoiesis erythroleuko-
thrombocytopoiesis Clinical Plethoric Cyanosis, chronic appearance, pulmonary disease, splenomegaly congenital cardiac disease Blood Pancytosis, No pancytosis erythrocytosis, leukocytosis Blood volume High High Red cell High High volume Plasma Normal or Low volume increased Arterial oxygen Normal Diminished saturation The most important end result of the extreme degree of panmyelopathy in PV is the development of an enormous mass of red blood cells in the circulation.
Clotting factors may be normal or slightly reduced, and compensatory
thrombocytopoiesis results in a moderately low to normal platelet count.
Thrombocytopoiesis in normal and sublethally irradiated dogs: response to human interleukin-6.
Does smoking affect
thrombocytopoiesis and platelet activation in women and men?
A combination of ineffective
thrombocytopoiesis and increased platelet sequestration and destruction accounts for the thrombocytopenia.