thrombocythaemia type 1
thrombocythaemia type 1A myeloproliferative disorder (OMIM:187950) characterised by increased platelets due to sustained proliferation of megakaryocytes, often leading to thrombosis and haemorrhage.
Caused by defects of THPO, which encodes thrombopoietin, a humoral growth factor required for megakaryocyte proliferation and maturation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.