thromboangiitis obliterans

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Related to thromboangiitis obliterans: arteriosclerosis obliterans


inflammation of a blood vessel (vasculitis) with thrombosis.
thromboangiitis obli´terans a disease affecting the medium-sized blood vessels, particularly the arteries of the lower limbs, which can cause severe pain and in serious cases lead to gangrene. The name refers to the clotting, pain, and inflammation occurring in this disease and to the fact that it can obliterate, or destroy, blood vessels. The cause has been thought to be excessive use of tobacco over a long period of time, and the number of cases has diminished strikingly in recent years. The intense pain is caused by thrombosis (formation of blood clots) in the lining of the arteries; when the clots grow larger, the blood flow slows and may stop entirely. Since every part of the body depends on the continuous flow of blood, affected areas such as fingers and toes, for example, soon begin to atrophy or develop ulcers. If the causes of the disease are not completely arrested, amputation may be necessary.

To treat the disease, the patient must stop smoking at once and entirely. This generally results in the partial healing of the affected membrane with a renewed flow of blood. However, more blood may have to be brought to damaged tissue by surgical methods of channeling detours or making canals in the clot itself. Sympathectomy may be tried to prevent any vasospastic component. Minor amputations of gangrenous tissue are often needed.

Special exercises called buerger-allen exercises are sometimes used to empty the engorged blood vessels and stimulate collateral circulation. These exercises can be done at home by patients and are usually prescribed to be done several times during the day. Patients are also instructed to avoid wearing any tight clothing, such as tight girdles, rolled garters, constricting belts, and other items that may impair circulation. They should also avoid sitting or standing in one position for long periods of time. Care should be used in the selection of shoes and stockings so that they fit properly and do not cause pressure against the blood vessels. Patients should be told to avoid walking barefoot or otherwise subjecting themselves to the hazards of trauma to the feet and legs. Should such an accident occur, no matter how minor it may seem, the patient must notify a health care provider so that treatment may be begun and infection and ulceration can be prevented.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

throm·bo·an·gi·i·tis ob·li·te·rans

inflammation of the entire wall and connective tissue surrounding medium-sized arteries and veins, especially of the legs of young and middle-aged men; associated with thrombotic occlusion and commonly resulting in gangrene.
Farlex Partner Medical Dictionary © Farlex 2012

throm·bo·an·gi·i·tis ob·lit·er·ans

(throm'bō-an'jē-ī'tis ob-lit'ĕr-anz)
Inflammation of the entire wall and connective tissue surrounding medium-sized arteries and veins, especially of the legs of young and middle-aged men; associated with thrombotic occlusion and commonly resulting in gangrene.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

thromboangiitis obliterans

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


Leo, Austrian-U.S. physician, 1879-1943.
Buerger disease - inflammation of the entire wall and connective tissue surrounding medium-sized arteries and veins, associated with thrombotic occlusion and commonly resulting in gangrene. Synonym(s): thromboangiitis obliterans; Winiwarter-Buerger disease
Buerger exercises - exercises specifically for patients with arterial insufficiency of their lower limbs. Synonym(s): Buerger-Allen exercises
Buerger-Allen exercises - Synonym(s): Buerger exercises
Winiwarter-Buerger disease - Synonym(s): Buerger disease
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Laboratory testing in patients with suspected Thromboangiitis Obliterans is used to exclude alternative diagnoses.
Lupus anticoagulant and anticardiolipin antibodies are detected in some patients with Thromboangiitis Obliterans but may also indicate an isolated thrombophilia.
Distal small- to medium-artery involvement, segmental occlusions, and "corkscrew"-shaped collaterals around areas of occlusion are typical angiographic findings in Thromboangiitis Obliterans. Proximal arteries should be normal without evidence of atherosclerosis.
PROGNOSIS: The prognosis for patients with Thromboangiitis Obliterans depends largely on the ability to discontinue tobacco use.
MANAGEMENT: Discontinuation of tobacco use is the definitive therapy for Thromboangiitis Obliterans. Complete smoking cessation is essential because even a few cigarettes a day may result in disease progression.
Surgical revascularization is usually not feasible in patients with Thromboangiitis Obliterans because of the distal and diffuse nature of the disease.
In a small study of patients with Thromboangiitis Obliterans, intramuscularly administered vascular endothelial growth factor resulted in the healing of ischemic ulcers and relief of rest pain.14 Several studies have evaluated autologous bone marrow mononuclear cell implantation for patients with critical limb ischemia resulting from Thromboangiitis obliterans.15-17 although short-term results of therapeutic angiogenesis have been promising, long-term safety and efficacy require further investigation.18
Antiendothelial cell antibodies in thromboangiitis obliterans. Am J Med Sci.
Antiphospholipid antibodies in thromboangiitis obliterans. Vasc Med.
The altered hemorheologic parameters in thromboangiitis obliterans: a new insight.
A prospective, case-control study of tobacco dependence in thromboangiitis obliterans (Buerger's disease).