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A glycoprotein, molecular weight approximately 72,500, formed and stored in the parenchymal cells of the liver and present in blood in a concentration of approximately 20 mg/100 mL. In the presence of thromboplastin and calcium ion, prothrombin is converted to thrombin, which in turn converts fibrinogen to fibrin, this process resulting in coagulation of blood; a deficiency of prothrombin leads to impaired blood coagulation.
Farlex Partner Medical Dictionary © Farlex 2012
thrombinogenProthrombin The molecular precursor to thrombin. See Prothrombin.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.