thrombin


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Related to thrombin: antithrombin, Thrombin time

thrombin

 [throm´bin]
1. the activated form of coagulation factor II (prothrombin), which catalyzes the conversion of fibrinogen to fibrin.
2. a preparation of this compound prepared from prothrombin of bovine origin, used as a topical hemostatic.
thrombin time (TT) the time required for plasma fibrinogen to form thrombin: exogenous thrombin is added to citrated plasma and the time to clot formation is measured. Prolonged TT is seen with abnormalities of fibrinogen and in the presence of heparin or degradation products of fibrin or fibrinogen.

throm·bin

(throm'bin),
1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.

thrombin

/throm·bin/ (throm´bin)
1. the activated form of coagulation factor II (prothrombin); it catalyzes the conversion of fibrinogen to fibrin.
2. a preparation derived from prothrombin of bovine origin together with thromboplastin and calcium; used therapeutically as a local hemostatic.

thrombin

(thrŏm′bĭn)
n.
A protease in blood that facilitates blood clotting by converting fibrinogen to fibrin.

thrombin

[throm′bin]
the key enzyme produced during coagulation by activation of prothrombin. Thrombin converts fibrinogen to fibrin, activates factors V, VIII, XI, and XIII, and causes platelet aggregation. See also blood clot , prothrombin.

thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.

throm·bin

(throm'bin)
1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.
Synonym(s): factor IIa.

thrombin

An enzyme in the blood that converts fibrinogen to fibrin, thus forming a blood clot.

thrombin

see BLOOD CLOTTING.

Thrombin

Thrombin is a protein produced by the body. It is a specific clotting factor that plays an important role in the blood clotting process.

thrombin

clotting cascade enzyme, formed from prothrombin

throm·bin

(throm'bin)
1. An enzyme (proteinase), formed in shed blood, which converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase.
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting; used as a topical hemostatic for capillary bleeding in general and plastic surgical procedures.
Synonym(s): factor IIa.

thrombin (throm´bin),

n a proteolytic enzyme formed from prothrombin by the action of thromboplastin, factor IV calcium (Ca++), and other factors. Thrombin forms fibrin from fibrinogen, speeds up the disruption of platelets, and activates factor V.

thrombin

an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets. A preparation from prothrombin of bovine origin is used as a topical hemostatic.

thrombin-thrombomodulin complex
thrombomodulin, a specific endothelial cell surface receptor, converts thrombin, a very weak activator of protein C in the anticoagulant pathway, to the status of a very active protein C activator.
thrombin time
the time required for a standardized solution of thrombin to clot plasma. It is a measure of the rate of conversion of fibrinogen to fibrin.
References in periodicals archive ?
Fibrin sealants (Tisseel, TachoSil) are made of thrombin and concentrated fibrinogen from human plasma.
Attempts to resolve the unsuitability of PT and APTT in investigating coagulation have led to the development of global assays such as thromboelastometry/thromboelastography (ROTEM/TEG) and thrombin generation tests in platelet-poor plasma, platelet-rich plasma, or whole blood.
Percutaneous thrombin injection is a simple, safe and effective technique for managing femoral pseudoaneurysms.
5) It blocks thrombin activity by binding the active site (N-terminus of bivalirudin) and the fibrinogen-binding exosite (C-terminus of bivalirudin) of circulating and clot-bound thrombin.
Another specific clotting factor mutation, prothrombin G20210A, increases prothrombin production and leads to excess generation of thrombin and exuberant clot formation.
novel agents that specifically modify the actions of thrombin, the most potent
KEY WORDS: bovine thrombin, manufacture, prions, transmission, virus
thrombin market has seen a faster growth, increasing from US$ 15 million in 1998 to US$141.
Fibrinogen, Plasma powder FG and Thrombin are odourless and tasteless.
This finding differs from results obtained by Lee et al, who injected thrombin into rat basal ganglia.
Recent studies indicate the presence of other proteolytically activated receptors (PARs), which may also be activated by thrombin (Cupit et al.
BB-10153 is an engineered form of human plasminogen, modified so that it is activated to plasmin by thrombin, rather than by the body's natural plasminogen activators such as tpA.