thrombasthenia


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thrombasthenia

 [throm″bas-the´ne-ah]
1. decreased platelet function; called also thromboasthenia.
Glanzmann thrombasthenia a hereditary platelet abnormality characterized by defective clot retraction, prolonged bleeding time, and related symptoms such as epistaxis and inappropriate bleeding. Clinically there is abnormal glass adhesion and impaired aggregation to ADP, collagen, and thrombin. Called also thrombasthenia and Glanzmann's disease.

throm·bas·the·ni·a

(throm'bas-thē'nē-ă),
An abnormality of platelets characteristic of Glanzmann thrombasthenia.
See also: Bernard-Soulier syndrome.
Synonym(s): thromboasthenia
[thromb- + G. astheneia, weakness]

thrombasthenia

Glanzmann's disease, see there.

throm·bas·the·ni·a

(throm'bas-thē'nē-ă)
An abnormality of platelets; to date, several varieties have been categorized; often finding characteristics of Glanzmann thrombasthenia.
Synonym(s): thrombo-aesthenia.
[thromb- + G. astheneia, weakness]

thrombasthenia

An obsolescent term for the condition in which blood platelets are present in normal numbers but do not function normally in their role in blood clotting. The condition may be inherited but is more commonly acquired. With the rapid growth in understanding of platelet function this term is likely to disappear.

throm·bas·the·ni·a

(throm'bas-thē'nē-ă)
Abnormality of platelets.
Synonym(s): thromboasthenia.
[thromb- + G. astheneia, weakness]
References in periodicals archive ?
A rare case of Glanzmann thrombasthenia. Int J Med Sci Public Health.
Excessive gingival bleeding in two patients with Glanzmann thrombasthenia. J Periodontol.
Criteria for diagnosis of Glanzmann's thrombasthenia (GT) were normal PT, aPTT, platelet count, and morphology; no curve with ADP, epinephrine, or collagen; and normal curve with ristocetin in platelet aggregation by lumiaggregometry.
(4.) Nurden AT Didry D, Kieffer N, McEver RP Residual amounts of glycoproteins IIb and IIIa may be present in the platelets of most patients with Glanzmann's thrombasthenia. Blood 1985;65:1021-4.
Describing Prof Caen as a man "who has dedicated his life to the study of Glanzmann's Thrombasthenia, " Mr Justice Astill said his evidence suggested that Mrs Wood could have survived.
Glanzmann thrombasthenia with bleeding or as prophylaxis before surgery Therapeutic Bleeds from oral cavity, mucous membrane or any other site with platelet dysfunction irrespective of the platelet count Platelets concentrate from whole blood can be prepared by PRP method or buffy-coat method and by plateletpheresis using cell separator.
[13] As per the studies conducted among women with menorrhagia, inherited platelet dysfunctions most commonly seen were isolated platelet factor 3 availability defect (48.4%), Glanzmann thrombasthenia (8.9%), storage pool disease (2.4%), arachidonic acid pathway defect (1.5%), and Bernard-Soulier syndrome (1.8%).
Glanzmann Thrombasthenia is rare inherited autosomal recessive disorder.
Hemarthrosis is rarely seen in disorders of platelet function and occurs even more rarely in Glanzmann thrombasthenia (GT), whereas episodes of hemarthrosis can be frequent in hemophilia (1).