three-vessel disease


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three-vessel disease

Coronary heart disease in which three coronary arteries have significant narrowing/stenosis. Three-vessel diseases are more commonly managed by bypass than by stenting or angioplasty.
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When analyses were conducted according to prespecified subgroups, CABG provided a 10-year survival benefit over PCI in patients with three-vessel disease (151 deaths after PCI versus 113 after CABG; HR 1.41; 95% CI 1.101.80; p=0.006).
The serum ICAM-1, YKL-40, and Lp-PLA2 levels were no significant difference among control group, single-vessel disease group, double-vessel disease group, and three-vessel disease group [ P > 0.05 for each comparison, [Figure 2].{Figure 2}
Patients with two- and three-vessel diseases had occlusion in IRA and [greater than or equal to] 70% stenosis in other epicardial vessels.
Regarding the severity of IHD, 21.8% had single-vessel disease (SVD),60.3% had double - vessel disease (DVD) while 17.9% had three-vessel disease (TVD).
He adds, however, that three-vessel disease or left main coronary artery disease is typically treated with bypass surgery anyway and that single- or double-vessel disease may be best treated with stents, again depending on all factors.
WENBIT involved 3,090 patients with established coronary heart disease, mostly stable angina and two- or three-vessel disease. They were randomized in a two-by-two factorial design to daily treatment with 0.8 mg of folic acid, 40 mg of [B.sub.6], plus 0.4 mg of [B.sub.12]; folic acid and [B.sub.12]; [B.sub.6] only; or placebo.
"There was a progressively higher skin cholesterol with greater vascular disease" that became highly significant for patients with three-vessel disease, noted Dr.
My initial impulse--a knee-jerk response--was three-vessel disease, therefore bypass.
tHcy in subjects with three-vessel disease was significantly higher subjects with than one-vessel disease (in-house, P = 0.0004; Abbott IMx, P = 0.0002; Bio-Rad HPLC, P = 0.0001; Bio-Rad EIA, P = 0.007), but not significantly higher than subjects with two-vessel CHD.
Regarding the extent and severity of CAD, Hodgkin patients had significantly more multi-vessel CAD: 10% had two-vessel disease and 24% had three-vessel disease compared to 6% and 9% of controls, respectively.
The levels of miRNA-145 in patients with three-vessel disease were significantly lower than those with one- or two-vessel disease (Ln_miRNA-145 −7.09 [+ or -] 1.01 vs.
In multivariate analysis, significant independent predictors of hard cardiac events were three-vessel disease at least 50% (hazard ratio, 5.21), left main coronary artery disease at least 50% (HR, 5.35), and the number of segments with noncalcified (HR, 1.84), mixed (HR, 1.39), and calcified plaques (HR, 1.62).