third-line therapy

third-line therapy

Any alternative to conventional–surgery, chemotherapy or RT for malignancy. Cf Unproven forms of cancer therapy.
References in periodicals archive ?
5% of patients were receiving guideline-recommended add-on third-line therapy, documenting a low level of adherence to published treatment guidelines.
Lithium traditionally has been prescribed as third-line therapy in refractory patients for severe unipolar depression.
Treatment of idiopathic overactive bladder often requires third-line therapy, which includes onabotulinumtoxinA, posterior tibial nerve stimulation, and sacral neuromodulation.
The National Comprehensive Cancer Network (NCCN) panel recommends nivolumab (OPDIVO) as a category 2A treatment option in patients with metastatic deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) colorectal cancer in second- or third-line therapy.
Data suggests that median survival on relapse is less than two years from the start of second-line therapy and around one year from the initiation of third-line therapy.
After treated with vinorelbine and/or gemcitabine as second- or third-line therapy, 46% of patients had stable disease.
This work specifically studied third-line therapy outcomes.
It is a randomised phase II trial of cabozantinib and erlotinib, alone or in combination, as second- or third-line therapy in patients with metastatic EGFR wild-type non-small cell lung cancer.
At 6-12 weeks after the third-line therapy and salvage therapy, the patients whose UBT results were negative were considered to have eradicated the infection.
Because of these side effects, anti-TNF antibodies are most often used only as a second- or third-line therapy, despite evidence that earlier use could improve patient outcomes.
Levofloxacin and linezolid are effective for close to 100% of isolates, but are best reserved for second-or third-line therapy.
At an FDA advisory panel meeting in September on the drug, the panel urged that it be used only as a third-line therapy.

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