Together with the results of our study, this supports limiting the use of ampicillin, in combination with a third-generation cephalosporin
, to neonates <1 month of age suspected of having severe infection and requiring meningitis cover.
baumannii infections were associated with high levels of third-generation cephalosporin
resistance (90%) but a low mortality rate (3%) despite only 48% of patients having received appropriate antimicrobials.
Fernandez-Crehuet et al., "Trends in yearly prevalence of third-generation cephalosporin
and fluoroquinolone resistant Enterobacteriaceae infections and antimicrobial use in Spanish hospitals, Spain, 1999 to 2010," Eurosurveillance, vol.
Postoperatively, a third-generation cephalosporin
and steroid were given.
Nosocomial outbreaks of infections caused by ESBL-producing gram-negative bacteria have also been reported, which are mainly the result of extensive and inappropriate use of third-generation cephalosporins
. Majority of ESBL-producing organisms are E.
We are urging legislative change along these lines because this is a major expense - a day's worth of a third-generation cephalosporin
can wipe out a nursing home's per diem, and nursing homes just don't have the money for this.
Avibactam is a non-beta-lactam beta-lactamase inhibitor which protects ceftazidime, a third-generation cephalosporin
, against degradation by certain beta-lactamases without decreasing the activity of ceftazidime against ceftazidime-susceptible organisms.
For children with non-type 1 penicillin hypersensitivity or mild type 1 hypersensitivity, a second-or third-generation cephalosporin
, such as cefuroxime, cefpodoxime, or cefdinir, can be considered, she said.
Sack, "Extended-spectrum [beta]-lactamase-mediated third-generation cephalosporin
resistance in Shigella isolates in Bangladesh," Journal of Antimicrobial Chemotherapy, vol.
It consists of ceftazidime, a third-generation cephalosporin
and an established and respected treatment for serious Gram-negative bacterial infections, and avibactam, a non-?
Early surgery is critical for treating necrotizing fasciitis, and empiric broad-spectrum intravenous antibiotic therapy--such as a combination of a third-generation cephalosporin
, penicillin or cloxacillin, an aminoglycoside, and either clindamycin or metronidazole--should be initiated immediately.