thiouracil


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thiouracil

(thī′ō-yo͝or′ə-sĭl′)
n.
A white crystalline compound, C4H4N2OS, that interferes with the synthesis of thyroxine, used to reduce the action of the thyroid gland, especially in the treatment of hyperthyroidism.
References in periodicals archive ?
"Treatment of hyperthyroidism with thiourea and thiouracil." JAMA, 1943; 122:78-81.
"Thiouracil derivatives of greater activity for the treatment of hyperthyroidism." J Clin Endocr.
Williams RH: Thiouracil treatment of thyrotoxicosis.
Anhydrous potassium carbonate (0.304 g, 2.2 mmol) was added to a solution of thiouracil 7 (0.29 g, 1mmol) in dry DMF (5mL) followed by addition of N-(2-chloroethyl) morpholine hydrochloride (0.21 g, 1.1 mmol).
Because PBDEs have the ability to interfere with thyroid hormone (TH) homeostasis, we included a reference group for TH-mediated effects by adding the goitrogen 6-n-propyl thiouracil (PTU) in the drinking water of pregnant females.
Pregnant rats fed the antithyroid pharmaceutical propyl thiouracil had both difficulty hearing low and intermediate frequency clicking sounds and loss of motor coordination (Goldey et al.
The inhibition of gonopodium development could be either an antiandrogenic effect blocking androgen receptors, or an indirect effect on steroid hormone production and secretion, as suggested after the observed inhibited regeneration of the gonopodium in guppies exposed to the antithyroid agent thiouracil (Hopper 1965).
Apart from its status as model drug, 5-FU has established therapeutic importance as a potent drug for the metastatic carcinoma of breast [24], treatment of solid tumours [26] and various types of cancer [28, 29], whereas thiouracils e.g.