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Thiouracil treatment of thyrotoxicosis.
Ochoa de Aspuru, "Horseradish peroxidase inhibition by
thiouracils," FEBS Letters, vol.
Anhydrous potassium carbonate (0.304 g, 2.2 mmol) was added to a solution of
thiouracil 7 (0.29 g, 1mmol) in dry DMF (5mL) followed by addition of N-(2-chloroethyl) morpholine hydrochloride (0.21 g, 1.1 mmol).
Because PBDEs have the ability to interfere with thyroid hormone (TH) homeostasis, we included a reference group for TH-mediated effects by adding the goitrogen 6-n-propyl
thiouracil (PTU) in the drinking water of pregnant females.
Pregnant rats fed the antithyroid pharmaceutical propyl
thiouracil had both difficulty hearing low and intermediate frequency clicking sounds and loss of motor coordination (Goldey et al.
The inhibition of gonopodium development could be either an antiandrogenic effect blocking androgen receptors, or an indirect effect on steroid hormone production and secretion, as suggested after the observed inhibited regeneration of the gonopodium in guppies exposed to the antithyroid agent
thiouracil (Hopper 1965).
Apart from its status as model drug, 5-FU has established therapeutic importance as a potent drug for the metastatic carcinoma of breast [24], treatment of solid tumours [26] and various types of cancer [28, 29], whereas
thiouracils e.g.
