thiothixene

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thiothixene

[thi″o-thik´sēn]

an antipsychotic agent that is a thioxanthene derivative; administered orally or intramuscularly as the base or the hydrochloride salt.

thiothixene

/thio·thix·ene/ (-thik´sēn) a thioxanthene derivative, used as the base or the hydrochloride salt for the treatment of psychotic disorders.

thiothixene

(thī′ō-thĭk′sēn′)

An antipsychotic drug, C₂₃H₂₉N₃O₂S₂, used primarily in the treatment of schizophrenia.

thiothixene

[-thī′ksēn]

a thioxanthene antipsychotic.

indications It is prescribed in the treatment of acute agitation and mild-to-severe psychotic disorders.

contraindications Parkinson's disease, concurrent administration of central nervous system depressants, hepatic or renal dysfunction, severe hypotension, or known hypersensitivity to this drug or to phenothiazine medications prohibits its use. It is not recommended for children under 12 years of age.

adverse effects Among the more serious adverse effects are hypotension, hepatotoxicity, extrapyramidal reactions, blood dyscrasias, and hypersensitivity reactions.

thiothixene (thī´ōthik´sēn),

n brand name: Navane;
drug class: thio-xanthene/antipsychotic;
action: depresses the cerebral cortex, hypothalamus, and limbic system, which control activity and aggression; blocks neurotransmission produced by dopamine at the synapse;
uses: treatment of psychotic disorders, schizophrenia, and acute agitation.

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References in periodicals archive ?

Borderline and schizotypal personality disorders treated with low-dose thiothixene versus placebo.

Personality disorders in intellectual disability: approaches to pharmacotherapy

Thiothixene is tapered and replaced by olan-zapine, 5 mg/d.

Psychotic and in pain: Mrs. P, age 58, has a history of depression, suicide attempts, and chronic pain. Eight months ago she developed psychotic symptoms. How would you treat her?

Response of borderline and schizotypal patients to small doses of thiothixene and haloperidol.

Pharmacologic treatment of borderline personality disorder: evidence suggests symptom-targeted pharmacotherapy can be beneficial

Amoxicillin-clavulanate * Augmentin Carbamazepine * Tegretol Chlorpromazine * Thorazine Ciprofloxacin * Cipro Citalopram * Celexa Donepezil * Aricept Galantamine * Reminyl Haloperidol * Haldol Levofloxacin * Levaquin Memantine * Namenda Olanzapine * Zyprexa Risperidone * Risperdal Rivastigmine * Exelon Thioridazine * Mellaril Thiothixene * Navane Valproate * Depakote

3 days of Cipro better than amoxicillin-clavulanate for uncomplicated UTI

1,2,4,20) High-potency neuroleptic drugs with strong D2 receptor antagonism, such as haloperidol and thiothixene, are more likely to cause NMS than are lower potency antipsychotic drugs, such as chlorpromazine or thioridazine.

Atypical neuroleptic malignant syndrome presenting as fever of unknown origin in the elderly

She had previous trials of several antipsychotics, including quetiapine, thiothixene, thioridazine, trifluoperazine, chlorpromazine, and haloperidol, all of which were ineffective and poorly tolerated because of serious side effects.

A dangerous GI complication: Ms. X, age 61, undergoes emergent surgery for intestinal obstruction. Her paranoid schizophrenia has been well controlled on clozapine, but the drug might be causing her GI distress. What would you do?

Current medications included insulin neutral protamine Hagedorn 30 U, pioglitazone 30 mg daily, nifedipine 120 mg daily, amiodarone 100 mg daily, thiothixene 30 mg twice a day, benztropine 1 mg twice a day, and potassium chloride 20 mEq daily.

Primary aldosteronism in type 1 diabetes mellitus

Commonly used thioxanthenes include chlorprothixene and thiothixene.

Drug-associated heat stroke

In these select few--who also had not responded to antidepressants or mood stabilizers--I have found thiothixene to be especially helpful to rapidly reduce anger.