Hematologic effects of intravesicular thiotepa
therapy for bladder carcinoma.
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa
, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Saarinen-Pihkala, "High-dose thiotepa
as consolidation therapy with autologous hematopoietic stem cell transplantation for high-risk Ewing family tumors: Single-institution experience," Journal of Pediatric Hematology/Oncology, vol.
McDonald, "Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa
conditioning therapy: incidence, risk factors, and outcome," Biology of Blood and Marrow Transplantation, vol.
As the exclusive US distributor for Tepadina, Amneal Biosciences began shipping the branded thiotepa
from its distribution centre in Kentucky.
 CTX 50 mg daily (after CTX 3 g/[m.sup.2] for the preparation of CD34+ and CTX 3 g/[m.sup.2], thiotepa
150 mg/[m.sup.2], and CBDCA AUC = 6, every 28 dd for 2 courses) Kummar et al.
Further progression with small bowel obstruction requiring debulking surgery and ultimately hospice care 3/Plastini Sp 6 cycles of doxorubicin, ifosfamide, and vincristine and is currently NED (10 months) 4/Grove NED at 4 years 5/Guerard Abdominal deposits at 6-10 months 6/Kostopoulou NED at 10 months 7/Rekhi Omental deposits at 1 year, lost to follow-up 8/ChouguIe Unknown 9/Zaloudek Treated with thiotepa
and 5-fluorouracil after recurrence at 1.4 years.
Epirubicin, gemcitabine, thiotepa
, doxorubicin, and adriamycin are cytotoxic agents that are only secondline therapies for superficial bladder cancer.
Our findings correlate well with the ability of the chelidonine-based thiotepa
derivate Ukrain to induce caspase activation in Jurkat cells as described previously (Habermehl et al.
Recurrence is the most undesirable treatment outcome of Pterygium surgery with overall recurrence rate of 18%.7,8 Various intraoperative and postoperative modalities including b-irradiation, topical thiotepa
, mitomycin C and 5-fluorouracil (5-FU) have been introduced to decrease recurrence rate of pterygium surgery.9,10
The Ukrain is a synthetic derivative of thiotepa
and the chelidonine, a main component of the greater celandine (Chelidonium majus L.) plant .
The latter tolerates 6-400-fold higher concentration of various antineoplastic agents compared to humans (e.g., Amethopterin, Nitromin, Cytoxan, ThioTEPA
, Myleran, Pactamycin, Carboplatin, Amsacrine, Thalicarpine, Chlorozotocin, and Fludarabine) .