Palladium(II) and platinum(II) bis(thiosemicarbazone
) complexes of the 2,6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor cells and reduced toxicity.
CID-M[S.sup.2] mass spectrum shows that a proton transfers from the quinolinic-N atom to N-4 atom of the thiosemicarbazone
occur before fragmentation of quasi-molecular ion (ion precursor).
Moreira et al., "Induction of Early Autophagic Process on Leishmania amazonensis by Synergistic Effect of Miltefosine and Innovative Semi-synthetic Thiosemicarbazone
1-5% mole palladium species has commonly been used in homogenous system with palladium being generated by [Pd.sup.2+] salts with ligands such as [Cl.sup.-], P[Ph.sub.3], dba, N-heterocyclic carbenes [5, 6], phosphorus and/or oxygen based ligands [1, 7], thiosemicarbazones
, and bis(thio)urea ligands  in the presence of organic and/or inorganic bases for neutralization of the reaction.
Abbas, "Synthesis of some new 4(3H)quinazolinone-2 -carboxaldehyde thiosemicarbazones
and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities," European Journal of Medicinal Chemistry, vol.
Pessanha et al., "Synthesis of thiosemicarbazone
and 4-thiazolidinone derivatives and their in vitro anti- Toxoplasma gondii activity," Bioorganic & Medicinal Chemistry Letters, vol.
Recently, crystal structures of thiosemicarbazone
derivatives bound to GP have been reported.
Saravana Kumar, M, Sreekanth, A, "2-Acetylpyridine N(4) Morpholine Thiosemicarbazone
(HAcpMTSc) as a Corrosion Inhibitor on Mild Steel in HCI." Ind.
Past treatment typically included massive doses of VIG, administration of thiosemicarbazone
, blood products, and supportive care for accompanying infections (7,9).
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone
cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.