thiosemicarbazone


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thi·o·sem·i·car·ba·zone

(thī'ō-sem'ē-kar'bă-zōn),
1. A compound containing the thiosemicarbazide radical, =N-NH-C(S)-NH2.
2. One of a group of tuberculostatic drugs that includes thiosemicarbazide, benzaldehyde thiosemicarbazone, and 4-aminoacetylbenzaldehyde thiosemicarbazone.
References in periodicals archive ?
Palladium(II) and platinum(II) bis(thiosemicarbazone) complexes of the 2,6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor cells and reduced toxicity.
CID-M[S.sup.2] mass spectrum shows that a proton transfers from the quinolinic-N atom to N-4 atom of the thiosemicarbazone occur before fragmentation of quasi-molecular ion (ion precursor).
Moreira et al., "Induction of Early Autophagic Process on Leishmania amazonensis by Synergistic Effect of Miltefosine and Innovative Semi-synthetic Thiosemicarbazone," Front.
1-5% mole palladium species has commonly been used in homogenous system with palladium being generated by [Pd.sup.2+] salts with ligands such as [Cl.sup.-], P[Ph.sub.3], dba, N-heterocyclic carbenes [5, 6], phosphorus and/or oxygen based ligands [1, 7], thiosemicarbazones [7], and bis(thio)urea ligands [8] in the presence of organic and/or inorganic bases for neutralization of the reaction.
Abbas, "Synthesis of some new 4(3H)quinazolinone-2 -carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities," European Journal of Medicinal Chemistry, vol.
Pessanha et al., "Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti- Toxoplasma gondii activity," Bioorganic & Medicinal Chemistry Letters, vol.
Recently, crystal structures of thiosemicarbazone derivatives bound to GP have been reported.
Saravana Kumar, M, Sreekanth, A, "2-Acetylpyridine N(4) Morpholine Thiosemicarbazone (HAcpMTSc) as a Corrosion Inhibitor on Mild Steel in HCI." Ind.
Past treatment typically included massive doses of VIG, administration of thiosemicarbazone, blood products, and supportive care for accompanying infections (7,9).
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.