thioridazine


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thioridazine

 [thi″o-rid´ah-zēn]
a phenothiazine used orally in the form of the base or the hydrochloride salt as an antipsychotic agent and sedative.

thioridazine

(thī′ə-rĭd′ə-zēn′)
n.
A phenothiazine drug, C21H26N2S2, that is used in the form of its hydrochloride to treat psychotic disorders.

thioridazine

A typical piperidine antipsychotic used for short-term management of depression with anxiety. Thioridazine decreases excitement, hypermotility, affective tension, and agitation by psychomotor inhibition. High doses are discouraged, given the concerns relating to cardiotoxicity and retinopathy.
 
Adverse effects
Drowsiness, pseudoparkinsonism, extrapyramidal symptoms, nocturnal confusion, hyperactivity, lethargy, psychotic reactions, restlessness, headache, dry mouth, blurred vision, constipation, nausea, vomiting, diarrhoea, nasal congestion, galactorrhoea, breast engorgement, amenorrhoea, ejaculation inhibition, peripheral oedema.

thioridazine

Mellaril® Pharmacology A chlorpromazine-like antipsychotic, metabolized to the therapeutically active mesoridazine

thioridazine

An antipsychotic drug used to treat SCHIZOPHRENIA and MANIA. A brand name is Melleril.
References in periodicals archive ?
(n = 183), the average prolongation of the QTc interval were of 38,5 msec for thioridazine, 20,6 msec for ziprasidone, 14,5 msec for quetiapine, 10,0 msec for risperidone, 6,4 msec for olanzapine and 4,7 msec for haloperidole.
Acute dystonic reactions was noted by the exposure of atypical antipsychotics risperidone, olanzapine, and the typical antipsychotic thioridazine in our study.
* Advise patients not to take BRISDELLE with thioridazine or pimozide [see Contraindications (4.2 and 4.3)].
In most cases where the retinal complications are stated, thioridazine is shown as the responsible drug.
The first generation antipsychotic thioridazine, even at therapeutic dosages, is frequently cited as causing TdP and sudden death by blocking the potassium channel [Ik.sub.r] and prolonging the QT interval [17].
(49) Among the traditional neuroleptics, chlorpromazine and thioridazine (50) are the agents most closely associated with diabetes mellitus, although the associations are weaker than those with olanzapine or clozapine.
Thioridazine had one of the strongest and most selective effects, causing differentiation of cancer stem cells but leaving normal ones alone.
Vancouver, May 27 (Xinhua-ANI): A team of Canadian scientists have discovered that thioridazine, a drug used to treat psychotic disorder, could successfully kill cancer stem cells in humans without the toxic side-effects on normal cells.
Scientists from Cancer Research UK and McMaster University in Ontario have found that an anti-psychotic drug called thioridazine has the capability to cure cancer.
The anti-psychotic drug thioridazine appears to "tame" deadly cancer stem cells, turning them into ordinary non-cancerous cells.
(37-39) Although case fatality rates in BAE are high ([greater than or equal to] 90%), some successful drug treatment combinations in balamuthiasis have included azoles (albendazole, fluconazole, or itraconazole), flucytosine, pentamidine, sulfadiazine; and synergistic anti-protozoal therapy with macrolide antibiotics (azithromycin or clarithromycin), phenothiazines (thioridazine or trifluoperazine), and the experimental anti-Leishmania agent used to treat visceral leishmaniasis, miltefosine.
A second section looks at monitoring recommendations for individual antipsychotics, among them clozapine, loxaprine, pericyazine, and thioridazine.