thioredoxin reductase


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thi·o·re·dox·in re·duc·tase

a flavoprotein that uses NADPH to re-reduce thioredoxin in the formation of deoxyribonucleotides.

PRDX5

A gene on chromosome 11q13 that encodes peroxiredoxin 5, which is involved in intracellular redox signalling. It reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided in the thioredoxin system.
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Inhibition of certain thiol-containing enzymes (Alcohol dehydrogenase, thioredoxin reductase, RNA polymerase) in the microorganisms by the rapid reaction of thiosulfinates with thiol groups is supposed to be the main mechanism involved in the antibiotic effect.
ANTIBACTERIAL ACTIVITY OF AQUEOUS EXTRACT OF GARLIC (ALLIUM SATIVUM) ON STANDARD STRAINS
Thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR) comprise a thioredoxin system which exists in nearly all living cells (Arner and Holmgren 2006).
Purification and partial characterization of thioredoxin reductase from the hepatopancreas of the mollusc Mytilus galloprovincialis Lam
Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells.
Safety and efficacy of microneedling with autologous platelet-rich plasma in chronic and stable alopecia areata
The selenium-containing enzyme thioredoxin reductase 1 (TrxR1) can be used to support the growth of various cells and to protect them from harmful forms of oxygen radicals, known as oxidative stress.
Possible new principle for cancer therapy
Holmgren, "Rat liver thioredoxin and thioredoxin reductase: purification and characterization," Biochemistry, vol.
The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis
The selected receptors used for the docking studies are carbonic anhydrase II (CA-II), cathepsins B (Cat B) [24], two different DNAs (DNA-1 [25] and DNA-2), DNA gyrase (Gyrase) [26], histone deacetylase7 (HDAC7) [27], histone protein in the nucleosome core particle (HIS) [28], BRAF kinase (Kinase) [29], recombinant human albumin (rHA) [30], ribonucleotide reductase (RNR) [31], topoisomerase II (Top II) [32], thioredoxin reductase (TrxR) [33], and thymidylate synthase (TS) [34].
The Anticancer Activities of Some Nitrogen Donor Ligands Containing bis-Pyrazole, Bipyridine, and Phenanthroline Moiety Using Docking Methods
1.8.1.B1) represents an interesting splicing variant of the animal thioredoxin reductase (TR), featured by the presence of a glutaredoxin-like domain appended at the N-terminal end of the TrxR module [1, 2].
Insight into the Mechanistic Basis of the Hysteretic-Like Kinetic Behavior of Thioredoxin-Glutathione Reductase (TGR)
TrxR: Thioredoxin reductase miRNA: MicroRNA UTR: Untranslated region [H.sub.2][O.sb.2]: Hydrogen peroxide.
miR-125a Suppresses TrxR1 Expression and Is Involved in [H.sub.2][O.sb.2]-Induced Oxidative Stress in Endothelial Cells
(iv) Thioredoxin reductase (TR) level: the kits were obtained from Biodiagnostic Company, Egypt, colorimetric method [17].
Tramadol Induced Adrenal Insufficiency: Histological, Immunohistochemical, Ultrastructural, and Biochemical Genetic Experimental Study
Yeung et al., "Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells," Free Radical Biology & Medicine, vol.
Regulatory Role of Redox Balance in Determination of Neural Precursor Cell Fate
Thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH, senses and responds to oxidative stress and modulates the redox status by scavenging ROS and by regulating several redox enzymes and signaling proteins.
Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches
Thioredoxin system comprised by thioredoxin reductase (TrxR/TXNDR), thioredoxin (Trx), and NADPH plays an important role in maintaining intracellular redox homeostasis.
TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma

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