thiopurine s-methyltransferase

thiopurine s-methyltransferase

(thī″ŏ-pūr′ēn″es′meth″ĭl-trans′fĕr-ās″),

TPMT

An enzyme that metabolizes and inactivates thiopurines (such as the drugs azathioprine and mercaptopurine). People with a genetic deficiency in TPMT have severe bone marrow suppression when they take thiopurines to manage diseases such as rheumatoid arthritis or inflammatory bowel disease.
References in periodicals archive ?
Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions.
There is no doubt that the thiopurine S-methyltransferase (TPMT) gene polymorphism is one of them.
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.
The thiopurine S-methyltransferase gene locus--implications for clinical pharmacogenomics.
They are: 1) the thiopurine S-methyltransferase (TPMT) deficiency and its relevance to immunosuppression; [30] and 2) the cytochrome P450-2D6 (CYP2D6) enzyme deficiency and its effect on psychiatric drug therapy.
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.
who investigated 6-thioguanine nucleotide (6-TGN) concentrations in patients with inflammatory bowel disease (IBD), concluded that standard and adapted dosing of azathioprine led to identical 6-TGN concentrations and remission rates and that therapeutic drug monitoring of thiopurine therapy was of no clinical benefit in patients with a wild-type thiopurine S-methyltransferase (TPMT) genotype.
First, there is now a commercially available diagnostic test measuring a patient's ability to produce the metabolic enzyme thiopurine S-methyltransferase (TPMT), which is essential for the metabolism of thiopurine medications used to treat acute lymphoblastic leukemia (ALL), the most common form of childhood cancer.
Among the assets that Genaissance is acquiring from DNA Sciences are: * DNA Sciences' Morrisville, North Carolina GLP compliant and CLIA licensed facility, which is a leader in providing clinical trial genotyping services and diagnostic tests to the pharmaceutical industry; * a patent estate, including exclusive licenses from The University of Utah and Yale University to patents for diagnosing Long QT Syndrome (LQT), a potential life threatening side-effect of various drugs; and * a commercially available thiopurine S-methyltransferase (TPMT) diagnostic test for identifying adverse effects caused by the thiopurine class of drugs, from which DNA Sciences is receiving royalties from its sub-licensees.
to a patent allowing for the identification of two gene forms, or alleles, that are important to the production of the human enzyme thiopurine S-methyltransferase (TPMT) and to related diagnostic uses.
In addition to the anabolic pathway, 6-MP is catabolized to 6-thiouric acid by xanthine oxidase and to 6-methyl mercaptopurine (6-MMP) by thiopurine S-methyltransferase (TPMT) (8).
For the article entitled "Association of Inosine Triphosphate 94C>A and Thiopurine S-Methyltransferase Deficiency with Adverse Events and Study Drop-Outs under Azathioprine Therapy in a Prospective Crohn Disease Study", by N.