The researchers found that compared with never-smokers, smokers had similar risks of corticosteroid-requiring flares (odds ratio, 1.16; 95 percent confidence interval [CI], 0.92 to 1.25), thiopurine
use (hazard ratio [HR], 0.84; 95 percent CI, 0.62 to 1.14), corticosteroid dependency (HR, 0.85; 95 percent CI, 0.60 to 1.11), hospitalization (HR, 0.92; 95 percent CI, 0.72 to 1.18), and colectomy (HR, 0.78; 95 percent CI, 0.50 to 1.21).
drugs in the treatment of autoimmune disorders.
One study (18) from a single academic medical center reported that the incidence of duplicate genetic testing was 3.3% for thiopurine
methyltransferase genotype, 0.3% for hemochromatosis gene mutation, and 0.9% for CYP450 2D6 mutations.
Prometheus Laboratories, Inc., (132) the Supreme Court held invalid a patent claiming a method of determining the proper dosage of a thiopurine
FOR PATIENTS WITH INFLAMMATORY bowel disease (IBD), thiopurine
exposure was associated with a significantly increased risk of herpes zoster, compared with 5-aminosalicylic acid (5-ASA) monotherapy, according to the results of two large retrospective cohort studies.
All UC patients at this intercept were analyzed at the 4-week, 6-week, and 3-month intervals after the occurrence of remission to determine patient characteristics, thiopurine
properties, and its efficacy and toxicity.
Nevertheless, after a new increase in the values of muscular and liver enzymes during the descending regimen of corticosteroids, treatment with azathioprine at a dose of 50 mg/24 h was started, pending the results of the thiopurine
methyltransferase (TPMT) polymorphism studies.
Common Cytochrome p4503A (CYP3A4 and CYP3A5) and Thiopurine
S-Methyl Transferase (TPMT) Polymorphisms In Turkish Population.
6-MP is catalyzed by the enzyme thiopurine
S-methyltransferase (TPMT), to form the inactive metabolite.
, who found that advanced fibrosis but not the thiopurine
methyltransferase (TPMT) genotype or activity predicted azathioprine toxicity in AIH patients.
It is a purine antagonist that is metabolized by thiopurine
methyltransferase (TPMT) to the active compound, 6-mercaptopurine; however this metabolism seems to be unrelated to the incidence of hypersensitivity .
Although the widespread introduction of 5-ASA, corticosteroids, thiopurine
, and TNF-[alpha] blockers into clinical practice significantly decreased the risk of major surgeries for IBD patients [9-12], high-quality evidences supporting the chemopreventive efficacy of these agents for CAC are either controversial or absent [13-18].