Evidences available support the deleterious effects of Methyl Thiophanate and its metabolite carbendazim on various aspects of male reproduction in hamsters, mice, rats and humans.
Hence, the present study was undertaken to investigate the reprotoxic effect of fungicide Methyl Thiophanate on fertility and the histology of testis and epididymis in adult male rabbit.
Groups 2, 3 and 4 were treated orally with Methyl Thiophanate dissolved in distilled water at a dose of 50, 100 and 150 mg/kg of body weight respectively for 31 days.
Light microscopic examinations revealed that the animals which were given Methyl Thiophanate for 4 weeks (G2, G3 and G4) exhibited a distinct histological difference with the control group.
2 Key producers of thiophanate methyl TC in China, 2010
1 Output of thiophanate methyl TC in China, 2005-2009
2 Price change of thiophanate methyl TC in China, 2005~2009
The findings of a Penn State fungicide-screening program identified imazalil sulfate as a candidate alternative for thiophanate methyl for the control of green mold.
A Ta2 isolate (342) that was collected in 2005 at a Pennsylvania mushroom operation in Chester County and shown to have high resistance to thiophanate methyl was used exclusively in this study.
In January, the Environmental Protection Agency (EPA) renewed the Section 18 exemption for Thiophanate methyl (Topsin M 70WP) as a mushroom spawn and supplement treatment to control green mold in Pennsylvania, Maryland and Delaware.
IR-4 has submitted its final report to EPA for Thiophanate methyl to be registered under Section 3 of the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), which would make the product available across the United States without a special exemption.
aggressivum, one of the causes of Trichoderma compost mold, and found that 14 out of 15 isolates of the fungus collected in Pennsylvania and Delaware were completely resistant to both benomyl (Benlate) and thiophanate
methyl (Topsin M).