Administer replacement hormones for hypothyroidism and manage hyperthyroidism with thionamides
and beta-blockers as appropriate.
Hyperthyroidism treatments such as thionamides
, iodine-131 ablation treatments and thyroid surgery should be avoided in asymptomatic patients (1).
1983; Idress, 1998) who reported that the increase in liver weight in broilers fed diets containing higher levels of canola meal, was probably due to a hydrolytic product of glucosinolates (allyl-isothiocyanate) which is present in canola meal and is toxic in nature like other thionamides
, resulting in hyperplasia of the liver.
Antithyroid drugs, specifically thionamides
(either propylthiouracil (PTU) or methimazole (MMZ)), are most often used as the primary treatment for persons with Graves' disease, in whom "remission," which is usually defined as remaining biochemically euthyroid for one year after cessation of drug treatment, is possible (9).
3) These patients often respond to thionamides
, which inhibit the processing of iodine into thyroid hormone.
Clinically, "mixed" AIT is common, in which patients seem to respond only to therapy with both thionamides
The sulphur-containing thionamides
found in brassica vegetables such as cabbage, cauliflower, broccoli and Brussels sprouts can prevent oxidation of iodide to iodine, and interfere with synthesis of thyroid hormones by impairing the binding of iodine to thyroglobulin.
In the United States, radioactive iodine treatment with or without initial treatment with thionamides
is a popular option for hyperthyroidism.
Restoration of euthyroidism by thionamides
is associated with GO improvement, but it is unclear whether this is because of a direct effect of thionamides
on GO or induced by the normalization of thyroid status.
, amitrole, and ethylenethiourea) decrease TH synthesis by inhibition of thyroid peroxidase (Capen 1997, 1998; Hill et al.
The human thyroid responds toxicologically to multiple anti-thyroid drugs, including excess iodide, propylthiouracil (PTU), and thionamides
, but the progression to cancer after repetitive administration has not been observed (Hard 1998; Hill et al.
Brousolle C, Ducottet X, Martin C, et al: Rapid effectiveness of prednisone and thionamides
combined therapy in severe amiodarone iodine-induced thyrotoxicosis.