continual swallowing) * Cardiac monitoring * Glucose monitoring * Medication administration * Thionamides
* Propylthiouracil (PTU) (effective, but severe risk for hepatic injury) * Methimazole * Anti-adrenergics * Beta-blockers * Calcium channel blockers (if beta-blockers contraindicated) * Glucocorticoids * Hydrocortisone * Dexamethasone * Iodine compounds * Potassium iodide * Antipyretics * Acetaminophen * Mental status assessment * Cooling methods (e.
Pharmacokinetics and pharmacotherapy of thionamides
Hyperthyroidism treatments such as thionamides
, iodine-131 ablation treatments and thyroid surgery should be avoided in asymptomatic patients (1).
In patients with thyrotoxicosis and underlying gland abnormality, in addition to withdrawal of amiodarone, definitive treatment includes the use of thionamides
, perchlorate, radio-iodine therapy, plasmapharesis, and surgery.
1983; Idress, 1998) who reported that the increase in liver weight in broilers fed diets containing higher levels of canola meal, was probably due to a hydrolytic product of glucosinolates (allyl-isothiocyanate) which is present in canola meal and is toxic in nature like other thionamides
, resulting in hyperplasia of the liver.
The continuation phase with thionamides
, ofloxacin (levofloxacin), cycloserin was implemented out-patient.
Rapid effectiveness of prednisone and thionamides
combined therapy in severe amiodarone iodine-induced thyrotoxicosis.
Antithyroid drugs, specifically thionamides
(either propylthiouracil (PTU) or methimazole (MMZ)), are most often used as the primary treatment for persons with Graves' disease, in whom "remission," which is usually defined as remaining biochemically euthyroid for one year after cessation of drug treatment, is possible (9).
3) These patients often respond to thionamides
, which inhibit the processing of iodine into thyroid hormone.
4] Normal [up arrow] [up arrow] pregnancy Hypothyroidism [down arrow] [down arrow] Subclinical [down arrow] [down arrow] hypothyroidism Adapted from American College of Obstetricians and Gynecologists (6) TABLE 3 Causes of hypothyroidism Iodine deficiency Hashimoto's thyroiditis Radioactive iodine therapy Thyroidectomy Viral thyroiditis Sheehan's syndrome Medications * Thionamides
* Lithium * Drugs that inhibit absorption of thyroid medication --Ferrous sulfate --Sucrafate --Cholestyramine --Antacids (aluminum hydroxide) TABLE 4 Fetal and neonatal effects of asymptomatic overt hypothyroidism STUDY LABORATORY OUTCOMES FINDINGS RECOMMENDATIONS Kooistra et al (12) [down arrow] Maternal hypothyroxinemia is a [FT.
Table 1 Some Examples of Interferences with Iodine Uptake and Utilization A) Cellular Uptake Inhibitors (1) * Perchlorate * Fluoride * Bromide * Thiocyanate B) Cellular Utilization Inhibitors 1) TPO inhibitors (1) * Thionamides
(Antithyroid drugs) * Goitrin * Bromide * Thiocyanate 2) Decreased [H.
For pregnant women who have hyperthyroidism, the antithyroid thionamides
are the first choice in treatment.