thiol ester

thi·ol es·ter

an ester formed from a carboxylic acid and a thiol (that is, RCO-SR'), for example, acetyl-coenzyme A.
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References in periodicals archive ?
Activation of [[Alpha].sub.2]-macroglobulin involves cleavage of an internal thiol ester bond which, in Limulus [[Alpha].sub.2]-macroglobulin, links Cys 999 with Glx 1002.
The reaction of LAM with proteases activates a unique internal [beta]-cysteinyl-[gamma]-glutamyl thiol ester bond, generating a reactive glutamyl residue and a free cysteinyl thiol.
Proteins of the [[alpha].sub.2]-macroglobulin family are unique for the presence of an internal thiol ester bond, which in LAM links Cys-999 with Gln-1002 (Ikawi et al., unpub.
Under the conditions used here, the binding of iodoacetamide was limited to the thiol of Cys-999, because the only [sup.14.C]-labeled tryptic peptides of [sup.14.C]-iodoacetamide-reacted MA-LAM had the peptide sequence of the thiol ester domain, PTG-CGIQNMIK (3).