Mercurous and mercuric ions impart their toxicological effects mainly through molecular interactions for instance mercuric ions have a greater affinity to bind to reduced sulfur especially in the thiol
containing molecules like GSH, cysteine, and metallothionein (MT) (124).
Around the core, more gold atoms formed an unusual pattern, joining the thiols
in shapes looking like handles.
In each of these multivariate models, the association of AF and more oxidized thiol
ratios remained statistically significant.
While the levels of reduced glutathione and total thiols
were elevated, the protein carbonyl content was decreased in brain among CA-fed mice.
5 M solution; Merck) and thiol
2-mercaptoethanol (Sigma Chemical Co.
This effect has been ascribed to an antioxidant effect of the added thiol
group, but it is also observed that apolipoprotein A-I Milano forms homodimers and heterodimers with apolipoprotein A-II, which may contribute to changes in function (23, 24).
The patent was granted to Rutgers University this July for polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol
, alcohol or phenol group within their structure into polymeric drug delivery systems.
Measurement of Double Bond or Thiol
Treatment with the thiol
antioxidant, Lcysteine (>0.
group (as thiolate) located close to the interchenar disulfide bond attacks its own disulfide bond.
film on the gold terminals serves as an adhesive for the polyaniline nanofibers.
To understand the mechanisms involved in the S-homocysteinylation of LDL, considered a risk factor for vascular disease (16), we measured total plasma thiol
and LDL-bound thiol
concentrations in a healthy population and investigated the relationships between total and apoprotein-bound thiols