Thiobarbiturates are useful intermediates in synthesis of heterocyclic compounds .
In continuation with our previous research work to develop greener protocols for the synthesis of bioactive heterocyclic compounds [35-36], here we wish to report a convenient method for the synthesis of heteroaryl barbiturates and thiobarbiturates using task-specific ionic liquid 1-butyl-3-methylimidazolium hydroxide [Bmim]OH under neat conditions by using conventional and microwave irradiation technique as shown in (Scheme 1).
Table-1: Antioxidant/DPPH radical scavenging activity of 5-arylidene barbiturates and thiobarbiturates
"The only well-documented, breed-specific anesthetic drug concern is with the use of thiobarbiturates
in Greyhounds," Dr.
Scharfe et al., "Binding free energy calculations and biological testing of novel thiobarbiturates
as inhibitors of the human NA[D.sup.+] dependent histone deacetylase Sirt2," MedChemComm, vol.
As a result of pioneering work of Qin Yan, a novel series of 5-benzylidene thiobarbiturates
(141) derivatives have been synthesized and screened for their antibacterial activity.
A myriad of determinands caught his interest: magnesium, calcium, beryllium, gold, copper, iron, and zinc; phosphorous, chloride, and protein-bound iodine; creatinine, urea, bilirubin, proteins, estrogens, nucleic acids, ketosteroids, and haptoglobin; cholesterol, triglycerides, free fatty acids, and phospholipids; salicylates, barbiturates, thiobarbiturates
, methotrexate, carbon monoxide, methanol, and ethanol; alkaline phosphatase, glucose-6-phosphatase, 5-'nucleotidase, cholinesterase, and creatine kinase.
Barbiturates and thiobarbiturates
are medicinally imperative class of heterocyclic compounds as they have been used as antipyretic , anticonvulsant , antiepileptic agents , sedatives, hypnotics [2-5], herbicidal and insecticidal , fungicidal  and antiviral agents .
According to Dade Behring Japan Ltd., there had been no reports on ammonia assay interference by thiobarbiturates
. The mechanism of this interference is not yet clear.
Organic molecules based on barbiturates and thiobarbiturates
have been investigated as promising non-linear optical materials and dyes .
treatment of s chizophrenic patients ; therefore, they are called "s leep cures ." Thiobarbiturates
are us ed as anes thetic agents clinically .
Barbiturates played an important role throughout their history: their traditional use as sedative and hypnotic agents, in schizophrenic patients, so-called "sleep cures." The discovery and the introduction of thiobarbiturates
in intravenous anesthesia made this class of compound potential clinical drugs .