thiobarbiturate

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thiobarbiturate

[thi″o-bahr-bich´er-it]

any of a group of compounds chemically related to barbiturates and with barbituratelike effects.

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In continuation with our previous research work to develop greener protocols for the synthesis of bioactive heterocyclic compounds [35-36], here we wish to report a convenient method for the synthesis of heteroaryl barbiturates and thiobarbiturates using task-specific ionic liquid 1-butyl-3-methylimidazolium hydroxide [Bmim]OH under neat conditions by using conventional and microwave irradiation technique as shown in (Scheme 1).

Synthesis and Biological Evaluation of Some Newly Synthesized Barbiturates and Their Derivatives by Using Task Specific Ionic Liquid [Bmim]OH

Table-4: [alpha]-Glucosidase inhibition activity of 5-arylidene barbiturates and thiobarbiturates based derivatives.

A Facile Single Pot Synthesis of Highly Functionalized Tricyclic Heterocycle Compounds via Sequential Knoevenagel-Michael Addition and their [alpha]-Glucosidase Inhibition, Antioxidants and Antibacterial Studies

According to Dade Behring Japan Ltd., there had been no reports on ammonia assay interference by thiobarbiturates. The mechanism of this interference is not yet clear.

Thiobarbiturates interfere with the Dade Behring aca ammonia test

treatment of s chizophrenic patients ; therefore, they are called "s leep cures ." Thiobarbiturates are us ed as anes thetic agents clinically [9].

5-Arylidene N,N-dimethylbarbiturates as Urease Inhibitors

A myriad of determinands caught his interest: magnesium, calcium, beryllium, gold, copper, iron, and zinc; phosphorous, chloride, and protein-bound iodine; creatinine, urea, bilirubin, proteins, estrogens, nucleic acids, ketosteroids, and haptoglobin; cholesterol, triglycerides, free fatty acids, and phospholipids; salicylates, barbiturates, thiobarbiturates, methotrexate, carbon monoxide, methanol, and ethanol; alkaline phosphatase, glucose-6-phosphatase, 5-'nucleotidase, cholinesterase, and creatine kinase.

Bennie Zak, PhD (September 29, 1919-July 29, 2005)

Barbiturates and thiobarbiturates are medicinally imperative class of heterocyclic compounds as they have been used as antipyretic [1], anticonvulsant [2], antiepileptic agents [3], sedatives, hypnotics [2-5], herbicidal and insecticidal [6], fungicidal [7] and antiviral agents [8].

Cyanoacetamide based Barbiturates, Thiobarbiturates and their Biological Studies

Organic molecules based on barbiturates and thiobarbiturates have been investigated as promising non-linear optical materials and dyes [1416].

Antibacterial and Antifungal Activities of 5-Arylidene-NN-Dimethylbarbiturates Derivatives By: Khalid Mohammed Khan Momin KhanAqeel Ahmad Aisha Irshad Leonardus Broto Sugeng Kardono Fazal Rahim Syed Moazzam Haider Sumbul Ahmed and Shahnaz Parveen

Barbiturates played an important role throughout their history: their traditional use as sedative and hypnotic agents, in schizophrenic patients, so-called "sleep cures." The discovery and the introduction of thiobarbiturates in intravenous anesthesia made this class of compound potential clinical drugs [1].