In continuation with our previous research work to develop greener protocols for the synthesis of bioactive heterocyclic compounds [35-36], here we wish to report a convenient method for the synthesis of heteroaryl barbiturates and thiobarbiturates
using task-specific ionic liquid 1-butyl-3-methylimidazolium hydroxide [Bmim]OH under neat conditions by using conventional and microwave irradiation technique as shown in (Scheme 1).
A myriad of determinands caught his interest: magnesium, calcium, beryllium, gold, copper, iron, and zinc; phosphorous, chloride, and protein-bound iodine; creatinine, urea, bilirubin, proteins, estrogens, nucleic acids, ketosteroids, and haptoglobin; cholesterol, triglycerides, free fatty acids, and phospholipids; salicylates, barbiturates, thiobarbiturates
, methotrexate, carbon monoxide, methanol, and ethanol; alkaline phosphatase, glucose-6-phosphatase, 5-'nucleotidase, cholinesterase, and creatine kinase.
Barbiturates and thiobarbiturates
are medicinally imperative class of heterocyclic compounds as they have been used as antipyretic , anticonvulsant , antiepileptic agents , sedatives, hypnotics [2-5], herbicidal and insecticidal , fungicidal  and antiviral agents .
Barbiturates played an important role throughout their history: their traditional use as sedative and hypnotic agents, in schizophrenic patients, so-called "sleep cures." The discovery and the introduction of thiobarbiturates
in intravenous anesthesia made this class of compound potential clinical drugs .