thioamide


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thi·o·am·ide

(thī'ō-am'īd),
An amide in which S replaces O.

thioamide

, thionamide (thī″ō-am′īd″) [ thio- + amide]
Any drug that inhibits the thyroid gland from making thyroid hormone. Examples include methimazole and propylthiouracil.
References in periodicals archive ?
Our unique design elements are highlighted in this poster and include pharmacophore modification, prodrug utilization, thioamide isosteres, and strategic lipophilicity incorporation.
THIOAMIDE DERIVATIVE MODULATES ANNEXIN V EXPRESSION IN HUMAN LIVER CARCINOMA HEPG2) CELLS 35.
The structural modifications from previously known antagonists were primarily in the D-ring region, involving a thioamide replacement of an amide.
Compound 4 was subjected to a standard procedure of transforming the cyano group into amidine via thioimidate salt [7], that is nitrile 4 was reacted with hydrogen sulphide affording thioamide 5, which was converted to thioimidate salt 6 with methyl iodide.
The sulfur atom of this compound, which is engaged in a thioamide bond with the indole ring, is responsible for a weak part of the toxicity of Amanita (e.
The antituberculous activity of thioamide in vitro and in the experimental animal (mouse and guinea pig).
Specifically, we demonstrate how these derivatives undergo aminolysis under mild conditions with both protected and unprotected amino acids, giving rise to stable thioamide species.
9:15 Amide and Thioamide Based Receptors for Anions
Studies indicated that thioamide based macrocycles show superior binding affinity for anions.
Susceptibility to ethambutol was found in 42% and to thioamides in 82% of candidates for the short regimen.
ciprofloxacin, levofloxacin and moxifloxacin); thioamides (e.
This suggests that the atypical Beijing genotype clone is evolving toward total drug resistance (defined as in vitro resistance to all first-line drugs, as well as aminoglycosides, cyclic polypeptides, fluoroquinolones, thioamides, serine analogs, and salicylic acid derivatives [30]) with acknowledgment of WHO's concern over the definition (31).