thiazolidinedione


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Related to thiazolidinedione: Alpha-glucosidase inhibitor, DPP-4 inhibitor

gli·ta·zone

(glit-ah'zōn),
Shorthand term for a class of oral hypoglycemics that have glitazone as a component in their names.
Synonym(s): thiazolidinedione

thiazolidinedione

(thī′ə-zō′lĭ-dēn′dĭ-ōn′)
n.
Any of a class of drugs that decrease insulin resistance and are used to treat type 2 diabetes.

thiazolidinedione

Glitazone, TZD Endocrinology A class of oral antidiabetic agents that inhibit tyrosine kinase, ↓ insulin resistance and correct hyperglycemia, hyperinsulinemia, hypertriglyceridemia Adverse effects Hepatic dysfunction. See Troglitazone, Tyrosine kinase inhibitor.

thiazolidinedione

(thī′ă-zŏ″lĭ-dēn-dī-ŏn)
A class of oral hypoglycemic agents that lowers blood sugars by reducing insulin resistance (improving tissue sensitivity to the effects of insulin) in fat and muscle, as well as the liver. A commonly used agent in this class is pioglitazone.

CAUTION!

Side effects of medications in this class include increased fluid retention, fractures, heart failure, liver injury, and weight gain.
References in periodicals archive ?
Macular edema: Post-marketing reports of new-onset or worsening diabetic macular edema with decreased visual acuity have been reported with thiazolidinediones, including pioglitazone.
A recent study shows that ferulic acid, a phytochemical present mostly in cell wall of a number of plants, when used in combination with commercial oral antidiabetic drugs like metformin and thiazolidinedione have an synergistic activity.
Likewise, of the patients with a known EF of less than 35%, only two were discharged on a thiazolidinedione, and three were discharged on metformin.
Although troglitazone is now off the market due to its hepatotoxicity, other thiazolidinediones that activate PPAR[gamma] are currently used as antidiabetic agents.
Or you may take a thiazolidinedione as your only diabetes medicine.
When used as add-on combination therapy with a thiazolidinedione, the incidence of peripheral edema for Onglyza 2.
Unless there are clinical champions for thiazolidinediones, of which there are precious few these days, the field of diabetes has moved on.
Pioglitazone and rosiglitazone belong to a class of drugs called thiazolidinediones that help to control blood sugar levels in patients with type 2 diabetes.
The sNDA is based on a double-blind, placebo-controlled clinical study evaluating BYETTA added to Lantus (insulin glargine), which showed many hard-to-treat patients with type 2 diabetes who were poorly controlled on basal insulin therapy with or without metformin and/or a thiazolidinedione achieved A1C control without weight gain or increasing their risk of hypoglycemia.
The 26 in whom thiazolidinediones were added to insulin gained 14.
Based on efficacy advantages over alternative compounds, the fastest demand gains among chiral pharmaceutical chemicals will evolve in erythropoietin hematopoietic agents, interferon and monoclonal antibody cancer therapies, long-acting antihistamines, neuraminidase-inhibiting antivirals, non-amphetamine anorexics, oxazolidinone antibiotics, and D-phenylalanine and thiazolidinedione antidiabetic preparations.
It delivers glycemic control in a single weekly dose and is indicated for the treatment of type 2 diabetes in adult patients in combination with metformin, a sulfonylurea, a thiazolidinedione, metformin plus a sulfonylurea or metformin plus a thiazolidinedione.