thiazolidinedione


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Related to thiazolidinedione: Alpha-glucosidase inhibitor, DPP-4 inhibitor

gli·ta·zone

(glit-ah'zōn),
Shorthand term for a class of oral hypoglycemics that have glitazone as a component in their names.
Synonym(s): thiazolidinedione

thiazolidinedione

(thī′ə-zō′lĭ-dēn′dĭ-ōn′)
n.
Any of a class of drugs that decrease insulin resistance and are used to treat type 2 diabetes.

thiazolidinedione

Glitazone, TZD Endocrinology A class of oral antidiabetic agents that inhibit tyrosine kinase, ↓ insulin resistance and correct hyperglycemia, hyperinsulinemia, hypertriglyceridemia Adverse effects Hepatic dysfunction. See Troglitazone, Tyrosine kinase inhibitor.

thiazolidinedione

(thī′ă-zŏ″lĭ-dēn-dī-ŏn)
A class of oral hypoglycemic agents that lowers blood sugars by reducing insulin resistance (improving tissue sensitivity to the effects of insulin) in fat and muscle, as well as the liver. A commonly used agent in this class is pioglitazone.

CAUTION!

Side effects of medications in this class include increased fluid retention, fractures, heart failure, liver injury, and weight gain.
References in periodicals archive ?
5-1) reduction) Hypoglycemic risk Moderate Low Low Effect on body Gain Gain Neutral weight Common adverse Hypoglycemia Edema, HF, Adverse effects effects fractures are rare Estimated cost Low Low High DPP-4, dipeptidyl peptidase-4; GLP-1, glucagon-like peptide-1; HbAlc, glycated hemoglobin; HF, heart failure; SGLT2, sodium-glucose cotransporter-2; SU, sulfonylurea; TZD, thiazolidinedione.
Whereas, GLUT4 and other specific adipocyte genes are ameliorated by thiazolidinedione treatment (Diaz-Delfin et al.
Although a definitive link between these drugs and an increased fracture risk has not yet been proved, the evidence amassed so far is suggestive enough to prompt caution in the treatment of patients with a thiazolidinedione (TZD), Dr.
It was also reported recently that the use of insulin-sensitizing thiazolidinedione drugs, such as rosiglitazone (Avandia), which are used to treat diabetes, is associated with a two-to threefold increase in the risk of suffering an osteoporotic hip fracture.
Galvus received European Union approval in September 2007 for use in patients in combination with the anti-diabetes medicines metformin, thiazolidinedione (TZD) or a sulphonylurea (SU).
After a review of postmarketing adverse event reports, FDA determined that an updated label with a boxed warning on the risks of heart failure was needed for the entire thiazolidinedione class of antidiabetic drugs.
Takeda is the originator of thiazolidinedione derivatives and ACTOS is a member of the thiazolidinedione class of "insulin-sensitizing" agents, and it directly targets insulin resistance.
The study reported dramatic effects, comparable to the current generation of diabetes and lipid-lowering thiazolidinedione drugs and statins, although only an inert placebo was used as a control.
Among those patients with a current EF available (n = 79), six patients were taking a thiazolidinedione and 15 were on metformin.
Medications of the thiazolidinedione class traditionally used for glycemic control in patients with type 2 diabetes seem to hold promise in this respect.
A human peroxisome-proliferator-activated receptor-[gamma] is activated by inducers of adipogenesis, including thiazolidinedione drugs.
Humanized monoclonal antibodies for breast, ovarian and prostate cancer, along with thiazolidinedione antidiabetic agents, will spur rapid growth in demand for bulk hormones and related agents.