thiamine pyrophosphate


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thiamine pyrophosphate

(thi'a-min, -men? pi?ro-fos'fat?)
An enzyme important in carbohydrate metabolism. It is the active form of thiamine. In people suspected of malnutrition, administering thiamine before the infusion of glucose-containing solutions prevents brain damage (Wernicke-Korsakoff's encephalopathy).
Synonym: cocarboxylase

Thiamine pyrophosphate (TPP)

The coenzyme containing thiamine that is essential in converting glucose to energy.
Mentioned in: Beriberi
References in periodicals archive ?
This principle of megadoses of vitamins appears to be an important fact in the modern era and our experience has shown repeatedly that a prolonged deficiency of thiamine cannot be addressed by physiological RDA doses in patients with an abnormal thiamine pyrophosphate effect (TPPE).
These findings are supported by a previous study of non-enzymatic glycosylation of proteins and glycation inhibition by thiamine and other inhibitors.18 Our results are in conformity with a previous report19 claiming that thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic AGEs compared with aminoguanidine.
Thiamine and thiamine pyrophosphate, both showed protective effects albeit to different extents.