thiamine hydrochloride


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thiamine hydrochloride

(thi'a-men?) [? + ?]
C12H17ClN4OS·HCl; a water-soluble, white crystalline compound that occurs naturally or can be synthesized. It is found in a wide variety of foods including sunflower seeds, pork, whole and enriched grains, legumes, brewers yeast, and fortified baked goods. The daily requirement for adults is 1.2 mg/day for men and 1.1 mg/day for women. Synonym: antiberiberi vitamin; vitamin B1

Function

It acts as a coenzyme of carboxylases in the decarboxylation of pyruvic acid and is therefore essential for the liberation of energy and the transfer of pyruvic acid into the Krebs cycle.

Deficiency Symptoms

Symptoms may include fatigue, muscle tenderness and increased irritability, disturbances of extraocular movement, loss of appetite, or cardiovascular disturbances. Alcoholics are especially prone to develop thiamine deficiency. Prolonged severe deficiency (e.g., during starvation) results in beriberi.

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References in periodicals archive ?
The company added Thiamine Hydrochloride Injection is indicated for the treatment of thiamine deficiency.