thiaminase


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thiaminase

 [thi-am´ĭ-nās]
an enzyme that catalyzes the splitting of thiamine into a pyrimidine and a thiazole derivative.

thi·am·i·nase

(thī-am'i-nās),
1. An enzyme present in raw fish that destroys thiamin and may produce thiamin deficiency in animals on a diet largely composed of raw fish.
2. A hydrolase cleaving thiamin into a pyrimidine moiety (that is, 2-methyl-4-amino-5-hydroxymethylpyrimidine) and a thiazole moiety (that is, 4-methyl-5-(2'-hydroxyethyl)thiazole); the pyrimidine moiety may appear in the urine as pyramin. Synonym(s): thiaminase II
References in periodicals archive ?
Moscow, "Sensitivity of breast cancer cell lines to recombinant thiaminase I," Cancer Chemotherapy and Pharmacology, vol.
It's also best to cook them to destroy the thiaminase, or you'll deplete your body of vitamin [B.sub.1].
The competition and predators have changed so much that these species have actually been lost." Alewife are also high in the enzyme thiaminase, she says, which breaks down vitamin [B.sub.1] (thiamine) and Contributes to mortality in the offspring of the alewife's predators.
A diet rich in raw fish often has high levels of thiaminase.
Plants contain the enzyme thiaminase and if consumed in large quantities by livestock may cause poisonings (Dunbar 1989).
Thiaminase enzymes can cause PEM by destroying thiamin in the rumen.
Problems with the nervous system, such as a deficiency in thiamine (one of the B vitamins), which is not necessarily due to a dietary deficiency, but a problem with the enzyme thiaminase, that breaks down the vitamin so that it cannot be used by the body.
So, thiamine inadequacy can be caused by decreased production by rumen microbes or factors that interfere with the action of thiamine, for example, plant thiaminases or thiamine analogs.