The prevalence of thiamin deficiency
in hospitalized patients with congestive heart failure.
can occur in people taking strong diuretics (known as loop diuretics) for congestive heart failure, and this deficiency itself can adversely affect heart function.
Chronic high intakes of alcohol predispose to thiamin deficiency in several ways:
Fortification with thiamin is a public health strategy which addresses Wernicke-Korsakoff syndrome (WKS), a result of thiamin deficiency.
Cobalt depresses oxygen uptake by the mitochondria of the heart and interferes with energy metabolism in a manner similar to the effects of thiamin deficiency
, which explained the pathophysiology of cardiomyopathy in these patients.
Discrepancies between the ETK activation test and clinical signs of thiamin deficiency have been reported previously, with several studies reporting no relationship between ETK activation results and thiamin intake (1-5).
Meanwhile, our experience with the HPLC assay suggests that measurement of TDP in red cells is the single most useful biochemical measurement for assessing thiamin status in patients who are at risk of thiamin deficiency.
Thiamin deficiency once killed thousands and perhaps millions of people in different countries across the world and particularly in Asia.
Thiamin deficiency still has the potential to be lethal to each one of us, because it is an essential nutrient.
The most widely used method to detect thiamin deficiency
is the indirect measurement of TDP in erythrocytes with either the transketolase activation test or the transketolase activity assay (5,6), but these tests are functional rather than a direct measurement of thiamin status and therefore may be influenced by factors other than thiamin deficiency
The Insight article by Roem presents a case study of severe hyperemesis gravidarum and consequent thiamin deficiency
Marginal thiamin deficiency
was subsequently diagnosed and she was treated with 100 mg intramuscular thiamin and discharged on 100 mg oral thiamin daily.