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A protein found in brown adipose tissue that acts as a thermogenic uncoupling protein of oxidative phosphorylation; it allows thermogenesis in this type of tissue.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Thermogenin amount and activity in hamster brown fat mitochondria: effect of cold acclimation.
This is consistent with the high levels of mitochondria in BAT, which uniquely express high levels of the inner mitochondrial membrane protein, uncoupling protein 1 (UCP-1), also known as thermogenin [15].
Unlike white fat in which fatty acids are metabolized to produce energy in the form of adenosine triphosphate, brown fat, owing to the presence of abundant mitochondria and uncoupling protein-1 (thermogenin), metabolizes these in the form of heat.
Kawada, et al., "Intake of Sweeteners and Pungent Ingredients Increases the Thermogenin Content in Brown Adipose Tissue of Rats," J.
Two enzymes, pyruvate dehydrogenase kinase isozyme 4 (PDK-4) and pancreatic lipase (PL), enable hibernation to occur by producing the alternative heat source thermogenin, and by slowing down metabolism and shifting the way fats are used.
(1999) reported that green tea and caffeine have thermogenin properties that promote fat oxidation and play a role in the control of body composition, probably through sympathetic activation of thermogenesis that could reduce obesity.