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A protein found in brown adipose tissue that acts as a thermogenic uncoupling protein of oxidative phosphorylation; it allows thermogenesis in this type of tissue.


A gene on chromosome 4q28-q31 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP1 is expressed only in brown adipose tissue.


a thermogenic protein involved in the lipolysis of brown adipose tissue.
References in periodicals archive ?
Thermogenin amount and activity in hamster brown fat mitochondria: effect of cold acclimation.
Intake of Sweeteners and Pungent Ingredients Increases the Thermogenin Content in Brown Adipose Tissue of Rats," J.
Two enzymes, pyruvate dehydrogenase kinase isozyme 4 (PDK-4) and pancreatic lipase (PL), enable hibernation to occur by producing the alternative heat source thermogenin, and by slowing down metabolism and shifting the way fats are used.