The company's lead clinical-stage programmes are: TG4010, a therapeutic vaccine
against non-small cell lung cancer, Pexa-Vec, an oncolytic virus against liver cancer, and TG4001, a therapeutic vaccine
against HPV-positive head and neck cancers.
The LEAPS platform technology is currently being utilized to develop an antigen specific therapeutic vaccine
for rheumatoid arthritis under a $1.5M grant from the U.S.
The company will now launch a phase 1 clinical trial of the therapeutic vaccine
NOUS-209 for gastric, colorectal and gastro-esophageal junction Microsatellite Instable (MSI) cancers (tumours characterised by a defective DNA mismatch repair system) in combination with the anti-PD-1 checkpoint inhibitor pembrolizumab.
Interestingly, LMP1-based therapeutic vaccine
also suppressed tumour growth and metastasis in mouse models .
Ultimately, in 2010, perseverance paid off and the first therapeutic vaccine
sipuleucel-T for the treatment of metastatic prostate cancer was approved by the FDA: In spite of its financial restructuring efforts, Dendreon earned $303.8 million in 2014 which was $20.1 million more than its 2013 sales revenue.
Indeed the high prevalence of Lupus disease in the United States as well as its ethnic diversity, reinforce our clinical development strategy for this therapeutic vaccine
. Full Phase IIb results are expected in mid-2017.
Tasker joins Altimmune from Genocea Biosceiences, where she was a senior director of clinical development and led the GEN-003 therapeutic vaccine
WASHINGTON -- Research is honing in on the best dose for a therapeutic vaccine
shown to reduce shedding of herpes simplex virus 2 in people with genital herpes infections, based on results presented at the annual meeting of the American Academy of Dermatology.
"We re-injected the activated dendritic cells into the mice as a therapeutic vaccine
", Professor PatriziaAgostinis explains."That vaccine alerted the immune system to the presence of dangerous cancer cells in the body.
Late last month, the companies entered into an agreement and plan of merger under which SciVac has agreed to acquire VBI to form a commercial-stage company with a licensed hepatitis B vaccine and a pipeline of preventative and therapeutic vaccine
candidates, the companies said.
The contract covers the development, manufacture, and marketing of a peptide therapeutic vaccine
for the treatment of pancreatic cancer.