Singer, "Influence of site on the therapeutic ratio
of adjuvant radiotherapy in soft-tissue sarcoma of the extremity," International Journal of Radiation Oncology Biology Physics, vol.
Safe intravenous dose, therapeutic index, therapeutic ratio and safety factor:
Safety measures also covered evaluation of therapeutic index, therapeutic ratio and safety factor for LTE.
Dose-response curves, safe intravenous (IV) dose, therapeutic index (TI), therapeutic ratio (TR) and safety factor (SF):
The therapeutic potential of LTE was evaluated and data showed that it has a therapeutic index of 1.99, a therapeutic ratio of 0.67 and a computed SF of 0.02 (Table 1).
* Water solubility and nonlinear pharmacokinetics may present problems in drugs with a narrow therapeutic ratio
, especially phenytoin.
Next, PET/CT optimizes the treatment plan to increase the radiation dose to the tumor and decrease the dose to sensitive organs (improving the therapeutic ratio
In this context, the concept of therapeutic ratios as described in the dosimetry section can effectively represent the results of treatment.
Property Re-188 Physical halflife 17.00 h Maximum beta energy (abundance) 2120.4 keV (71.1%) 1965.4 keV (25.6%) Gamma energy (abundance) 155.0 keV (15%) Maximum penetration in tissue 10 mm (average 3.1 mm) Table 2: Re-188 HEDP therapeutic ratios. Re-188 HEDP ratios N/V M/V M/N B/RM Mean value 1.8 9.0 5.0 1.9 N/V and M/V are given in mGy/MBq/Voxel .
For example, a range of responses to a drug (efficacy, side effects, therapeutic ratios
) in a target populations can be modeled by additive effects of DNA polymorphisms when a drug is given and the recipients have agreed to have their DNA and clinical response analyzed.