therapeutic ratio


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ther·a·peu·tic ra·ti·o

the ratio of the maximally tolerated dose of a drug to the minimal curative or effective dose; LD50 divided by ED50.
Farlex Partner Medical Dictionary © Farlex 2012

ther·a·peu·tic in·dex

(thār'ă-pyū'tik in'deks)
The ratio of LD50 to ED50, used in quantitative comparisons of drugs.
Synonym(s): therapeutic ratio.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

therapeutic ratio

The ratio obtained by dividing the effective therapeutic dose by the minimum lethal dose. Synonym: curative ratio
Medical Dictionary, © 2009 Farlex and Partners

ther·a·peu·tic ra·ti·o

(thār'ă-pyū'tik rā'shē-ō)
Ratio of maximally tolerated dose of a drug to the minimal curative or effective dose; LD50 divided by ED50.
Medical Dictionary for the Dental Professions © Farlex 2012
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References in periodicals archive ?
Singer, "Influence of site on the therapeutic ratio of adjuvant radiotherapy in soft-tissue sarcoma of the extremity," International Journal of Radiation Oncology Biology Physics, vol.
Safe intravenous dose, therapeutic index, therapeutic ratio and safety factor:
Safety measures also covered evaluation of therapeutic index, therapeutic ratio and safety factor for LTE.
Dose-response curves, safe intravenous (IV) dose, therapeutic index (TI), therapeutic ratio (TR) and safety factor (SF):
The therapeutic potential of LTE was evaluated and data showed that it has a therapeutic index of 1.99, a therapeutic ratio of 0.67 and a computed SF of 0.02 (Table 1).
* Water solubility and nonlinear pharmacokinetics may present problems in drugs with a narrow therapeutic ratio, especially phenytoin.
Next, PET/CT optimizes the treatment plan to increase the radiation dose to the tumor and decrease the dose to sensitive organs (improving the therapeutic ratio).
In this context, the concept of therapeutic ratios as described in the dosimetry section can effectively represent the results of treatment.
Property Re-188 Physical halflife 17.00 h Maximum beta energy (abundance) 2120.4 keV (71.1%) 1965.4 keV (25.6%) Gamma energy (abundance) 155.0 keV (15%) Maximum penetration in tissue 10 mm (average 3.1 mm) Table 2: Re-188 HEDP therapeutic ratios. Re-188 HEDP ratios N/V M/V M/N B/RM Mean value 1.8 9.0 5.0 1.9 N/V and M/V are given in mGy/MBq/Voxel [4].
For example, a range of responses to a drug (efficacy, side effects, therapeutic ratios) in a target populations can be modeled by additive effects of DNA polymorphisms when a drug is given and the recipients have agreed to have their DNA and clinical response analyzed.

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