therapeutic ratio


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ther·a·peu·tic ra·ti·o

the ratio of the maximally tolerated dose of a drug to the minimal curative or effective dose; LD50 divided by ED50.

ther·a·peu·tic in·dex

(thār'ă-pyū'tik in'deks)
The ratio of LD50 to ED50, used in quantitative comparisons of drugs.
Synonym(s): therapeutic ratio.

therapeutic ratio

The ratio obtained by dividing the effective therapeutic dose by the minimum lethal dose. Synonym: curative ratio

ther·a·peu·tic ra·ti·o

(thār'ă-pyū'tik rā'shē-ō)
Ratio of maximally tolerated dose of a drug to the minimal curative or effective dose; LD50 divided by ED50.
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References in periodicals archive ?
Safe intravenous dose, therapeutic index, therapeutic ratio and safety factor:
Safety measures also covered evaluation of therapeutic index, therapeutic ratio and safety factor for LTE.
Dose-response curves, safe intravenous (IV) dose, therapeutic index (TI), therapeutic ratio (TR) and safety factor (SF):
This ultimately enhances the therapeutic ratio since maximal doses are delivered to the tumor while sparing adjacent normal tissue.
Preliminary research has shown that B-L-Fd4C has potent activity against both HIV and HBV with an acceptable therapeutic ratio.
Unfortunately, however many PDE-4 inhibitors have failed in early development due to low therapeutic ratios.
In addition to greater potency than other oligonucleotide chemistries, LNA drugs are resistant to degradation when given systemically, have long tissue half lives, are taken up readily by many tissues, and have improved therapeutic ratios over first and second generation antisense drugs.
By comparison, the therapeutic ratios of the traditional chemotherapy drugs are at best 6:1.

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