The preclinical data that show that GLYX-13 has an extraordinary therapeutic ratio
for this drug class support our belief that our approach has the potential to achieve the goal of separating the positive antidepressant activity of NMDA receptor modulators from their adverse CNS effects.
GLYX-13 has demonstrated a wide therapeutic ratio
(500:1) between efficacy and side effects, which is the largest therapeutic ratio
of any reported molecule that interacts at the NMDA receptor.
Summary: -- Ciclesonide represents a new generation of ICS for treatment of chronic asthma -- Unique properties of ciclesonide: high pulmonary deposition, on site-activation, prolonged pulmonary retention, rapid systemic clearance, -- Therefore: improved therapeutic ratio
(improved local efficacy, less systemic effects) MEDIA CONTACT: Lester B.
He noted that Cogent's development program addresses many of the problems previously encountered with oral muscarinic receptor agonists, including poor bioavailability, short-half-life requiring frequent dosing, and poor therapeutic ratio
Hansen, Vice President of Research and Development at Immunomedics and an inventor on the new patent, stated: "Many antibiotic and anticancer drugs work by maintaining blood levels that kill both the microorganisms or cancer cells, while also providing some toxicity to the body's normal cells, thus achieving a low therapeutic ratio
(ratio of drug in diseased cells to that in normal cells).
In preclinical studies in animals, the company's pretargeting technology achieved a significant improvement in the therapeutic ratio
(the dose delivered to tumor divided by the dose delivered to blood) compared to conventional radioimmunotherapy accompanied by rapid, complete regressions of chemotherapy-resistant human lung cancer tumors.
QS-21 showed low toxicity and high therapeutic ratio
We believe MR-guided SBRT may improve that therapeutic ratio
with online adaptive treatments, which enable real-time imaging, contouring, optimization and quality assurance while the patient is on the table.
50]), therapeutic index and therapeutic ratio
were discussed to authenticate its prospective beneficial effect.
13) To overcome the issue of inadequate dose, the radiation oncologist must attempt to increase the therapeutic ratio
to avoid normal tissue complications while increasing the dose to the tumor and, ultimately, increasing local control (Figure 6).
The drug has a very narrow therapeutic ratio
, with neurotoxicity and nephrotoxicity being the limiting factors.
We conclude that interferon alpha-2b possesses greater therapeutic activity in vitro than ribavirin, with a potentially greater therapeutic ratio