of post-ovulatory follicles was continuous with the epithelial cell layer lining the ovigerous lamellae.
Additionally, in the present study, BMP15 and GDF9 were also expressed in the pellet of cells, where granulosa and theca
cells were expresed.
AR has been primarily localized in the theca
interna cells of preantral follicles, granulosa cells of preantral and antral follicles, and both theca
and granulosa cells of dominant follicles .
Very few macrophages are seen in the stroma and theca
layer of the stromal embedded follicle.
Diffuse, usually weak TNF-[alpha] expression was seen in theca
layer compared with the control group.
Granulose cells, gc; theca
cells, tc; and connective tissue, ct.
Recent studies have shown that HGF can suppress apoptosis in ovarian granulosa cells and mediates the positive feedback loop between theca
cells and granulosa cells, which can promote the dramatic cell growth required for folliculogenesis [41, 42].
Meantime, this can lead to abnormal proliferation or excessive apoptosis of follicular cells such as the high LH dependent theca
cellular proliferation  and follicular atresia induced granulosa cell inactivation [68-70] in PCOS and depletion of oocytes pool in premature ovarian failure .
Hyperreactio luteinalis (HL) refers to moderate to marked cystic enlargement of the ovaries due to multiple benign theca
However, many studies indicate that GDF9 and BMP15 have critical roles in ovarian architecture of most species and are essential factors for adequate follicular development, interfering considerably in the function, growth and formation of granulosa and theca
cells during the growth of the follicle (Vitt and Hsueh, 2001; Otsuka et al., 2011).
Expression of this gene has been reported in testes, ovarian theca
cells, and H295 adrenal carcinoma cells (19).
A layer of cells (Theca
folliculi) was first appearing with spindle-shaped nucleoli and was enveloped of each oocyte (Fig.3, e).