thalassemia minor


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.

thalassemia

 [thal″ah-se´me-ah]
a heterogeneous group of hereditary hemolytic anemias marked by a decreased rate of synthesis of one or more hemoglobin polypeptide chains, classified according to the chain involved (α, β, δ); the two major categories are α- and β-thalassemia.
α-thalassemia (alpha-thalassemia) that caused by diminished synthesis of alpha chains of hemoglobin. The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis. The heterozygous form may be asymptomatic or marked by mild anemia.
β-thalassemia (beta-thalassemia) that caused by diminished synthesis of beta chains of hemoglobin. The homozygous form is called t. major and the heterozygous form is called t. minor.
thalassemia ma´jor the homozygous form of β-thalassemia, in which hemoglobin A is completely absent; it appears in the newborn period and is marked by hemolytic, hypochromic, microcytic anemia; hepatosplenomegaly; skeletal deformation; mongoloid facies; and cardiac enlargement.
thalassemia mi´nor the heterozygous form of β-thalassemia; it is usually asymptomatic, but there may be mild anemia.
sickle cell–thalassemia a hereditary anemia involving simultaneous heterozygosity for hemoglobin S and thalassemia.

thal·as·se·mi·a mi·nor

[MIM*141800-142310 passim]
the heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and quite variable hematologically, with target cells, mild hypochromic microcytosis, and often slightly reduced hemoglobin level with slightly increased erythrocyte count; types of hemoglobin are variable and depend on the gene involved.

thalassemia minor

Thalassemia trait Hematology The carrier state for beta thalassemia–heterozygosity, possession of one thalassemia gene; the person is essentially normal

thal·as·se·mi·a mi·nor

(thal'ă-sē'mē-ă mī'nŏr)
The heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and widely variable hematologically, with target cells, mild hypochromic microcytosis, and often slightly reduced hemoglobin level with slightly increased erythrocyte count; types of hemoglobin are variable and depend on the gene involved.
Synonym(s): thalassaemia minor.

Cooley,

Thomas B., U.S. pediatrician, 1871-1945.
Cooley anemia - the syndrome of severe anemia with multiple organ disorders. Synonym(s): thalassemia major
Cooley trait - Synonym(s): thalassemia minor

thal·as·se·mi·a mi·nor

(thal'ă-sē'mē-ă mī'nŏr) [MIM*141800142310 passim, MIM*141800, MIM*141800-142310 passim]
Heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and quite variable hematologically.
Synonym(s): thalassaemia minor.
References in periodicals archive ?
iv) If a person having thalassemia minor or major then there are chances that his sisters brothers and other
Because of the negligible effect of Cap+1 mutation on these hematological parameters and Hb-A2 levels it is difficult to diagnose beta thalassemia minor caused by Cap+1(A-C) mutation.
Common Hemoglobinopathies, Which Present as Thalassemia Minor in the Heterozygous State and as Thalassemia Major in Homozygous or Compound Heterozygous States
Apart from Hb E Variants, 10(21%) cases were of thalassemia minor, 7(15%) cases of HbS were found of which 2 were HbS traits and 5 were HbS disease.
Finally, they concluded that the E&F index showed with great sensitivity and specificity to be the best discriminant function to differentiate between IDA and thalassemia minor cases.
Notably, there are two genetic forms of alpha thalassemia minor (severe).
The thalassemia minor conditions produce minimal decrements in the Hb concentration, whereas thalassemia intermedia and thalassemia major may be associated with moderate to severe decreases in Hb concentration.
When one of the beta globin chain gene is normal and other abnormal, it is thalassemia minor.
Moinuddin, a senior hematologist said thalassemia that was largely un-heard of in years 1947 to 1970s was found to be increasingly diagnosed in people with traces of both thalassemia minor and thalassemia major.
Hb D/[beta]-thalassemia patients have a disease that has clinical manifestations ranging from mild to moderate disease, resembling either thalassemia minor or thalassemia intermedia [4].