thalassemia minor


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thalassemia

 [thal″ah-se´me-ah]
a heterogeneous group of hereditary hemolytic anemias marked by a decreased rate of synthesis of one or more hemoglobin polypeptide chains, classified according to the chain involved (α, β, δ); the two major categories are α- and β-thalassemia.
α-thalassemia (alpha-thalassemia) that caused by diminished synthesis of alpha chains of hemoglobin. The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis. The heterozygous form may be asymptomatic or marked by mild anemia.
β-thalassemia (beta-thalassemia) that caused by diminished synthesis of beta chains of hemoglobin. The homozygous form is called t. major and the heterozygous form is called t. minor.
thalassemia ma´jor the homozygous form of β-thalassemia, in which hemoglobin A is completely absent; it appears in the newborn period and is marked by hemolytic, hypochromic, microcytic anemia; hepatosplenomegaly; skeletal deformation; mongoloid facies; and cardiac enlargement.
thalassemia mi´nor the heterozygous form of β-thalassemia; it is usually asymptomatic, but there may be mild anemia.
sickle cell–thalassemia a hereditary anemia involving simultaneous heterozygosity for hemoglobin S and thalassemia.

thal·as·se·mi·a mi·nor

[MIM*141800-142310 passim]
the heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and quite variable hematologically, with target cells, mild hypochromic microcytosis, and often slightly reduced hemoglobin level with slightly increased erythrocyte count; types of hemoglobin are variable and depend on the gene involved.

thalassemia minor

Thalassemia trait Hematology The carrier state for beta thalassemia–heterozygosity, possession of one thalassemia gene; the person is essentially normal

thal·as·se·mi·a mi·nor

(thal'ă-sē'mē-ă mī'nŏr)
The heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and widely variable hematologically, with target cells, mild hypochromic microcytosis, and often slightly reduced hemoglobin level with slightly increased erythrocyte count; types of hemoglobin are variable and depend on the gene involved.
Synonym(s): thalassaemia minor.

Cooley,

Thomas B., U.S. pediatrician, 1871-1945.
Cooley anemia - the syndrome of severe anemia with multiple organ disorders. Synonym(s): thalassemia major
Cooley trait - Synonym(s): thalassemia minor

thal·as·se·mi·a mi·nor

(thal'ă-sē'mē-ă mī'nŏr) [MIM*141800142310 passim, MIM*141800, MIM*141800-142310 passim]
Heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and quite variable hematologically.
Synonym(s): thalassaemia minor.
References in periodicals archive ?
9] The differential diagnosis includes iron deficiency, thalassemia minor resulting from [Alpha]- or [Beta]-thalassemia trait or from variant hemoglobins such as HbE and Hb Lepore, anemia of inflammation, congenital sideroblastic anemia, and lead poisoning.
Quantitative anisocytosis as a discriminant between iron deficiencies and thalassemia minor.
A new red blood cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor.
Table 1 shows the data of thalassemia minor patients and controls.
In comparison with CDC data, height for age was below the 3rd percentile in 10% of thalassemia minor children, while it was below the 25th percentile in 52% and below the 50th percentile in 78%.
All of the selected thalassemia minor children were healthy without any medical disorder.
She said all clinics, hospitals and centres handling and treating such patients will ensure that blood relatives of these children are all screened for Thalassemia minor and trait.
Sagheer Ahmad said that it is high time to bring the laws to prevent the Thalassemia Major in Pakistan by motivating Thalassemia Minor couples to undergo the blood screening before marriage and not to go for inter- marriage in case they are Thalassemia Minor .