thalassaemia


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to thalassaemia: Thalassaemia minor

thal·as·se·mi·a

, thalassanemia (thal'ă-sē'mē-ă, -ă-să-nē'mē-ă)
Any of a group of inherited disorders of hemoglobin metabolism in which there is impaired synthesis of one or more of the polypeptide chains of globin; several genetic types exist, and the corresponding clinical picture may vary from barely detectable hematologic abnormality to severe and fatal anemia. People of Mediterranean, extraction are more often affected than others by this type of anemia.
Synonym(s): thalassaemia, thalassanaemia.
[G. thalassa, the sea, + haima, blood]

thalassaemia

One of several hereditary abnormalities of synthesis of the globin chains of HAEMOGLOBIN leading to severe ANAEMIA. The disorder is common in the area surrounding the Mediterranean sea. When the abnormality is HETEROZYGOUS (thalassaemia minor), disability is minimal, but when HOMOZYGOUS (thalassaemia major), anaemia may be severe with breathlessness, jaundice, spleen enlargement and sometimes physical and mental retardation. Treatment is by blood transfusion and bone marrow transplantation. From the Greek words thelazia , the sea, and haima , blood.

thal·as·se·mi·a

, thalassanemia (thal'ă-sē'mē-ă, -ă-să-nē'mē-ă)
Any of a group of inherited disorders of hemoglobin metabolism with impaired synthesis of one or more polypeptide chains of globin; several genetic types exist.
Synonym(s): thalassaemia, thalassanaemia.
[G. thalassa, the sea, + haima, blood]
References in periodicals archive ?
Deletions of one to three normal [alpha]-globin genes causes an increasing reduction in [alpha]-globin chain synthesis in carriers of [alpha]+ Thalassaemia (-[alpha]/[alpha][alpha], --/[alpha][alpha] or -[alpha]/-[alpha]), [alpha]0 thalassaemia (-[alpha]/[alpha] [alpha] o r - [alpha]/-[alpha]), [alpha] 0 thalassaemia (--/[alpha][alpha]) and haemoglobin H disease (--/-[alpha]).1-3 Commonest deletional ATs found in Pakistani population are -[alpha] 3.7 with a frequency of 8.3% and the rare forms include -[alpha] 4.2 (0.2%) and [alpha][alpha][alpha] anti-3.7(0.9%).4 Beta Thalassaemia (BT) results in reduced synthesis ([beta]+) or complete su ppression ([beta]0) of [beta]-globin chain synthesis.
Dr Siyal expressed that he was trying his best to get approval of such large amount of grant as Thalassaemia Centre would no need to seek the assistance from individual benevolent.
Speaking to authorities, he said the first and most important priority of the Pakistan Bait-ul-Mal is to provide maximum facilities to patients suffering from thalassaemia.
of thalassaemia patients is decreasing and we should also remember to continue our struggle for making Pakistan a thalassaemia-free country, he added.
The parents having thalassaemia children had to go through great ordeals, because of the problems arising from transfusion of blood to their off springs, he added.
Thalassaemia is a genetic blood disorder and treatment for those with thalassaemia major included regular blood transfusions as well as medications.
Globally, thalassaemia affects tens of thousands of patients and in its severest form and without adequate care may lead to death in early childhood.
She said the work area of the directorate would be expanded across the province as Thalassaemia is a nightmare for most of the people in Balochistan.
According to thalassaemia statistics from 2015, the average carrier rate in Dubai of the recessive disease gene was estimated to be 4.5 per cent of the population.
Effective awareness programmes and compulsory pre-marital screening have led to a decrease in the number of thalassaemia cases in Dubai with only one beta thalassaemia major reported in 2017 and one mortality in the same year.
The CM announced that the Punjab government would table a bill in the provincial assembly soon to make thalassaemia test mandatory before marriage.