tetrodotoxin


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tetrodotoxin

 [tet´ro-do-tok″sin]
a highly lethal neurotoxin present in numerous species of puffer fish and in newts of the genus Taricha (in the latter it is called tarichatoxin); ingestion results in tetrodotoxism.

tet·ro·do·tox·in (TTX),

(tet'rō-dō-tok'sin),
A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and some newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. Tetrodotoxin blocks voltage-gated Na+ channels in excitable tissues.

tetrodotoxin

/tet·ro·do·tox·in/ (tet´ro-do-tok″sin) a highly lethal neurotoxin present in numerous species of puffer fish and in certain newts (in which it is called tarichatoxin ); ingestion rapidly causes malaise, dizziness, and tingling about the mouth, which may be followed by ataxia, convulsions, respiratory paralysis, and death.

tetrodotoxin

(tĕ-trō′də-tŏk′sĭn)
n.
A potent neurotoxin, C11H17N3O8, found in many pufferfishes and certain other animals, including some salamanders and crabs.

tetrodotoxin

A potent, heat-stable neurotoxin concentrated in certain tissues—liver, gonads, intestines and skin of fishes of order Tetraodontoidea (ocean sunfish, porcupine fish, and pufferfish/fugu); it is also present in lethal amounts in the California newt and eastern salamander.
 
Mechanism of action
Tetrodotoxin blocks conduction of sodium across membranes and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it.
 
Clinical findings
Paraesthaesias begin 10-45 minute after ingestion, commonly as intraoral and tongue tingling; often associated with nausea, vomiting, light-headedness, vertigo, a sense of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, fixed dilated pupils.
 
Management
IV hydration, gastric lavage, activated charcoal.

tetrodotoxin

Toxicology A potent heat-stable neurotoxin concentrated in fishes of order Tetraodontoidea; tetrodotoxin blocks conduction of sodium across membranes, and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it, causing 50 deaths/yr in Japan Clinical Paresthesias begin 10-45 mins after ingestion, commonly as intraoral and tongue tingling, often associated with N&V, lightheadedness, vertigo, feelings of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, and fixed dilated pupils Management IV hydration, gastric lavage, activated charcoal

tetrodotoxin

Puffer fish toxin, one of the most powerful known neurotoxins with a mortality of about 50%. There is no known antidote.

tetrodotoxin

a highly lethal neurotoxin present in numerous species of puffer and toadfish (suborder Tetraodontoidea) and in newts of the genus Taricha (tarichatoxin); ingestion results, within minutes, in malaise, dizziness and tingling about the mouth, which may be followed by ataxia, convulsions, respiratory paralysis and death.
References in periodicals archive ?
Tetrodotoxin resistance in garter snakes: An evolutionary response of predators to dangerous prey.
Lagocephalus lunaris is an Indo-Pacific species of puffer fish and is one of the only species known to contain high concentrations of tetrodotoxin naturally in the meat, making safe preparation of this product impossible (9).
Abbreviations: DMSP, dimethylsulfoniopropionate; PA, pyrrolizidine alkaloid; STX, saxitoxin; TTX, tetrodotoxin.
Standards for flourometric High Phase Liquid Chromatography (HPLC) were prepared from tetrodotoxin with citrate buffer available from Sigma (product number T8024-1MG).
However if the respiratory system and the heart are kept in motion, a person may survive tetrodotoxin ingestion.
He will oversee the further clinical development of WEX's lead product, Tetrodotoxin (TTX) for the treatment of cancer pain.
The poison, tetrodotoxin, is highly concentrated in the organs, especially the liver and the ovaries.
Local authority's decision of declaring it as inedible was right its internal organs contain the neurotoxin Tetrodotoxin [a potent marine toxin].
The tail of the monkfish is especially prized for its delicate flavor, while ingesting puffer fish flesh can lead to serious illness or even death from tetrodotoxin poisoning.
Instead, as tests showed, the flatworm contained a poison called tetrodotoxin.