tetrodotoxin


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tetrodotoxin

 [tet´ro-do-tok″sin]
a highly lethal neurotoxin present in numerous species of puffer fish and in newts of the genus Taricha (in the latter it is called tarichatoxin); ingestion results in tetrodotoxism.

tet·ro·do·tox·in (TTX),

(tet'rō-dō-tok'sin),
A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and some newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. Tetrodotoxin blocks voltage-gated Na+ channels in excitable tissues.

tetrodotoxin

/tet·ro·do·tox·in/ (tet´ro-do-tok″sin) a highly lethal neurotoxin present in numerous species of puffer fish and in certain newts (in which it is called tarichatoxin ); ingestion rapidly causes malaise, dizziness, and tingling about the mouth, which may be followed by ataxia, convulsions, respiratory paralysis, and death.

tetrodotoxin

(tĕ-trō′də-tŏk′sĭn)
n.
A potent neurotoxin, C11H17N3O8, found in many pufferfishes and certain other animals, including some salamanders and crabs.

tetrodotoxin

A potent, heat-stable neurotoxin concentrated in certain tissues—liver, gonads, intestines and skin of fishes of order Tetraodontoidea (ocean sunfish, porcupine fish, and pufferfish/fugu); it is also present in lethal amounts in the California newt and eastern salamander.
 
Mechanism of action
Tetrodotoxin blocks conduction of sodium across membranes and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it.
 
Clinical findings
Paraesthaesias begin 10-45 minute after ingestion, commonly as intraoral and tongue tingling; often associated with nausea, vomiting, light-headedness, vertigo, a sense of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, fixed dilated pupils.
 
Management
IV hydration, gastric lavage, activated charcoal.

tetrodotoxin

Toxicology A potent heat-stable neurotoxin concentrated in fishes of order Tetraodontoidea; tetrodotoxin blocks conduction of sodium across membranes, and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it, causing 50 deaths/yr in Japan Clinical Paresthesias begin 10-45 mins after ingestion, commonly as intraoral and tongue tingling, often associated with N&V, lightheadedness, vertigo, feelings of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, and fixed dilated pupils Management IV hydration, gastric lavage, activated charcoal

tetrodotoxin

Puffer fish toxin, one of the most powerful known neurotoxins with a mortality of about 50%. There is no known antidote.

tetrodotoxin

a highly lethal neurotoxin present in numerous species of puffer and toadfish (suborder Tetraodontoidea) and in newts of the genus Taricha (tarichatoxin); ingestion results, within minutes, in malaise, dizziness and tingling about the mouth, which may be followed by ataxia, convulsions, respiratory paralysis and death.
References in periodicals archive ?
Tetrodotoxin Poisoning Associated with Eating Puffer Fish Transported from Japan--California 1996, MORBIDITY & MORTALITY WKLY.
This suggests that tetrodotoxin helps flatworms kill, but it doesn't protect adult flatworms from being eaten.
The flatworm has tetrodotoxin along with some closely related chemicals, the researchers report in an upcoming Proceedings of the National Academy of Sciences.
tetrodotoxin, procaine, and of magnesium on the field-stimulated
Both technologies rely on lipid microspheres carrying tetrodotoxin, a potent local anesthetic, and a laser producing a focused beam of near-infrared (NIR) light, which is able to penetrate tissues without causing direct injury.
Active groups of saxitoxin and tetrodotoxin as deduced from action of saxitoxin analogs on frog muscle and squid axon.
Nearly three-fourths of the patients said their pain was noticeably reduced during the tetrodotoxin test, and two patients reported complete relief at some times, says Neil Hagen of the University of Calgary in Alberta, who presented the findings in May at the North American Pain Conference in Vancouver, British Columbia.
He claims they poison their intended victims with extract of puffer fish which contain tetrodotoxin.
A lethal dose of tetrodotoxin is about 1 mg and there is no known antidote.
WEX Pharmaceuticals' lead product based on Tetrodotoxin (TTX), a highly selective sodium channel blocker, is in Phase III clinical development for the treatment of cancer-related pain.
Blowfish poison, called tetrodotoxin, is nearly 100 times more poisonous than potassium cyanide.