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A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and some newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. Tetrodotoxin blocks voltage-gated Na+ channels in excitable tissues.
A potent neurotoxin, C11H17N3O8, found in many pufferfishes and certain other animals, including some salamanders and crabs.
tetrodotoxinA potent, heat-stable neurotoxin concentrated in certain tissues—liver, gonads, intestines and skin of fishes of order Tetraodontoidea (ocean sunfish, porcupine fish, and pufferfish/fugu); it is also present in lethal amounts in the California newt and eastern salamander.
Mechanism of action
Tetrodotoxin blocks conduction of sodium across membranes and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it.
Paraesthaesias begin 10-45 minute after ingestion, commonly as intraoral and tongue tingling; often associated with nausea, vomiting, light-headedness, vertigo, a sense of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, fixed dilated pupils.
IV hydration, gastric lavage, activated charcoal.