tetraploidy


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Related to tetraploidy: polyploidy

tetraploidy

 [tet´rah-ploi″de]
the state of having four sets of chromosomes (4n).
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In this context, we observed (i) increased G1 cell population in [H.sub.2][O.sub.2]-treated C10 cells following Chk1 knockdown and (ii) induction of tetraploidy in C10 cells under acidic conditions, indicating override of the mitotic spindle checkpoint in Chk1-downregulated C10 cells.
I should point out that our technology does not accurately evaluate for tetraploidy. Therefore the error rate attributable to the test itself is probably about 1 per 1,000," according to the fertility specialist.
One limitation is an inability to detect polyploidy such as triploidy or tetraploidy. This problem can be circumvented through the use of a FISH preparation prior to aCGH.
Failure in cytokinesis or asymmetric cytokinesis results in formation of binucleate blastomeres that leads to tetraploidy or spindle pole abnormalities and thus chromosomal chaos (16).
Artificial parthenogenesis in starfish eggs: behavior of nuclei and chromosomes resulting in tetraploidy of parthenogenotes produced by the suppression of polar body extrusion.
The investigators focused on DNA aneuploidy and tetraploidy and on alterations in the genes for the tumor-suppressor proteins TP53 and CDKN2A accompanied by a loss of heterozygosity (LOH) for those genes.
Mantel tests of the average GSCs (Table 3) among the ploidy levels further demonstrated that the genetic distances among the tetraploidy, pentaploidy, and hexaploidy are significant (P < 0.01).
Among the genetic factors accounting for first-trimester pregnancy losses, 50% are autosomal trisomies, 20-25% are monosomies, 16% are triploidy, and 8% tetraploidy. It's estimated that in 2%-3% of couples with recurrent first-trimester pregnancy loss, one of the partners has a balanced translocation.
plicatulum plants and the subsequent induction of tetraploidy (SARTOR et al., 2009) made genetic improvement of the Plicatula group through interspecific crosses possible.
This approach may lead to false-positive results, given that tetraploidy (4 copies of each chromosome) is a natural product of cell division.