Toopcham et al  reported that the tripeptide Met-CysSer, containing the branched-chain amino acid Met at the Nterminus, exhibited higher ACE inhibitory activity than that of tetrapeptide
Trapoxin, an antitumor cyclic tetrapeptide
, is an irreversible inhibitor of mammalian histone deacetylase.
Lactoferrin-derived peptides active towards influenza: identification of three potent tetrapeptide
The use of trapoxin, an antitumor cyclic tetrapeptide
, showed increased histone acetylation, and led to the identification of the protein responsible: the first histone deacetylase.
Asperterrestide A, a cytotoxic cyclic tetrapeptide
from the marine-derived fungus Aspergillus terreus SCSGAF0162.
The purpose of this research is to determine the effects of Cl[O.sub.2] and [O.sub.3] on the amino acids tyrosine, tryptophan, phenylalanine, and proline, a dipeptide Tyr-Phe and a tetrapeptide
Through that transaction, Allergan also acquired rapastinel, an intravenously administered NMDA receptor modulating tetrapeptide
. Subsequently, rapastinel received Breakthrough Therapy designation from the FDA and Allergan is currently evaluating the compound in Phase 3 studies in major depressive disorder.
Djuran, "A study of the reactions of a methionine- and histidine-containing tetrapeptide
with different Pd(II) and Pt(II) complexes: selective cleavage of the amide bond by platination of the peptide and steric modification of the catalyst," Dalton Transactions, no.
Among peptide inhibitors of the uPAR system, a tetrapeptide
named UPARANT, designed to mimic the amino acid sequence through which uPAR binds its interactors in the cellular membrane, including the formyl peptide receptors (FPRs), displays resistance to enzymatic digestion, high stability in blood and plasma, and optimal effectiveness as a uPAR inhibitor .
HC toxin, a cyclic tetrapeptide
first isolated from the secondary metabolite of Helminthosporium carbonum , is also highly efficient in enhancing HDP expression in both porcine intestinal epithelial and alveolar macrophages.
Another estimated structure showing absorbance at 1710 [cm.sup.-1] may be a tetrapeptide
imide structure like compound 10 (n = 1; q = 1), which could form by coupling of two dipeptides, for instance, Val-Asp from 5c in Figure 14.