: Compound from Japanese, Chinese herbs shows promise for blocking Ebola virus.
Inhibition of stimulant-induced activation of phagocytic cells with tetrandrine
. J Leukoc Biol.
is a major bisbenzylisoquinoline alkaloid isolated form Stephania tetrandra S.
The presence of protoberberine and bisbenzylisoquinoline alkaloids like berberine, oxyberberine, palmatine, oxyacanthine, berbamine, and tetrandrine
are mainly responsible for the diverse pharmacological properties of the genus [4, 5].
Su, "Protective effects of silybin and tetrandrine
on the outcome of spontaneously hypertensive rats subjected to acute coronary artery occlusion," International Journal of Cardiology, vol.
ameliorates dextran-sulfate-sodium-induced colitis in mice through inhibition of nuclear factor -kB activation," International Journal of Colorectal Disease, vol.
, a bisbenzylisoquinoline alkaloid has been found to induce apoptosis at a high concentration (30 [micro]M) by repressing AKT activity in HCC cells.
Mei et al., "Synergistic antitumour activity of sorafenib in combination with tetrandrine
is mediated by reactive oxygen species (ROS)/Akt signaling," British Journal of Cancer, vol.
Researchers have identified several Chinese herbal medicinal ingredients that can mediate P-gp efflux, including tetrandrine
, dauricine , and quercetin .
Liu et al., "Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine
for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies," Drug Development and Industrial Pharmacy, vol.
Zhang et al., "An efficient Trojan delivery of tetrandrine
by poly(N-vinylpyrrolidone)-block-poly(epsilon-caprolactone) (PVP-b-PCL) nanoparticles shows enhanced apoptotic induction of lung cancer cells and inhibition of its migration and invasion," International Journal of Nanomedicine, vol.
In addition to the five monomers described above, many other monomers are also found to be closely related to the BMID axis, including tetrandrine
, notoginsenoside , Lycium barbarum polysaccharide , allicin , astragaloside IV [113, 114], quercetin , and resveratrol .