tetrahydroaminoacridine

tetrahydroaminoacridine

A drug that has been used experimentally to try to improve the situation of people with ALZHEIMER'S DISEASE.
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Elucidation of mitochondrial effects by tetrahydroaminoacridine (tacrine) in rat, dog, monkey and human hepatic parenchymal cells.
Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles.
Last March, an FDA advisory panel recommended against the approval of tetrahydroaminoacridine (THA), a potential Alzheimer treatment that inhibits the breakdown of acetylcholine (SN: 3/23/91, p.
Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A (1986) Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type.
In announcing its conclusion last week, the panel cited a lack of convincing scientific evidence demonstrating the efficacy and safety of the drug, known as tetrahydroaminoacridine (THA).
The study focused on tetrahydroaminoacridine (THA), a compound that inhibits a crucial brain enzyme required to break down the neurotransmitter acetylcholine (SN: 11/15/86, p.
Enthusiasm over the potential of tetrahydroaminoacridine (THA) as a treatment for Alzheimer's disease waned last fall, amid questions about the original research and the suspension of a large clinical trial because of serious side effects (SN: 11/7/87, p.
If new agents such as tetrahydroaminoacridine (THA) [6] are introduced, the demand for assessment is likely to grow further.
Clinical trials of the drug, called tetrahydroaminoacridine or THA, were suspended late last month after some patients developed signs of liver toxicity.
Researchers from the University of California at Los Angeles and several other institutions gave tetrahydroaminoacridine (THA) to patients with "moderate to severe" Alzheimer's disease, diagnosed by psychological and biochemical testing as well as by magnetic resonance imaging.