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Randomized placebo-controlled trials with tricyclic and tetracyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs) were analyzed.
Tricylcic and tetracyclic antidepressants (TCAs) also can result in dryness in the mouth and nasal mucosa and also contribute to gastroesophageal reflux.
For example, decreased libido has been reported in studies examining the sexual side effects of tricyclic and tetracyclic antidepressants, monoamine oxidase inhibitors, and SSRIs.
John's wort for one to three months with subjects who received placebo or antidepressant therapy with medications such as tricyclic or tetracyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) for the same period.