cosyntropin

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cosyntropin

 [ko″sin-tro´pin]
a synthetic corticotropin used in the screening of adrenal insufficiency on the basis of plasma cortisol response after intramuscular or intravenous injection.

co·syn·tro·pin

(kō-sin-trō'pin),
α1-24- or β1-24-Corticotropin; a synthetic corticotrophic agent, comprising the first 24 amino acyl residues of human ACTH, which sequence is found in several other species and which retains the full biologic activity of the complete ACTH; the remaining 15 residues differ among species and confer specific immunologic properties.

cosyntropin

(kō′sĭn-trō′pĭn)
n.
A synthetic corticotropin.
References in periodicals archive ?
ii) Adrenocorticotropic hormone administration: A standardised dose (1 [micro]g/kg), of ACTH (Synacthen Depot, tetracosactide 1 mg/mL, Lot S1358, Novartis, South Africa) was administered once to each of the six cows at time 0 [27].
The tender number includes the following medicines: Tender no: 1, Atc code: H01aa02, Generic name: Tetracosactide, Dispensing form: Injection, Strength: 0.25 mg / ml, Unit value: 0.25 mg, Quantity in units: 10,410.
Inadequate cortisol response to the tetracosactide (Synacthen [R]) test in non-classic congenital adrenal hyperplasia: an exception to the rule?
Early morning cortisol was subsequently found to be low at 242 nmol/L and short Synacthen test with 250 mcg of tetracosactide did not show adequate cortisol response (Table 1).
The majority of patients underwent screening for hypopituitarism with a tetracosactide test as well as 72-hour fast to exclude endogenous hyperinsulinaemia, as in our index patient.
The drug is a depot formulation of Synacthen (tetracosactide), a synthetic 24 amino acid melanocortin receptor agonist.
Addition of the ACTH analog tetracosactide caused an 8-fold increase in corticosterone secretion.
Tetracosactide (Synacthen Depot, 1 mg/mL) was obtained from Ciba (V.
The synthetic ACTH analog tetracosactide was added (11 nM) to stimulate ACTH-regulated enzyme activity in the slices.
Adrenal slices exposed to tetracosactide maintained a constant rate of [sup.3]H-leucine incorporation into protein [counts per minute (CPM) per milligram protein], which remained linear for 60 hr (Figure 1A).
In slices exposed to tetracosactide, accumulation of corticosterone and 11-deoxycorticosterone in the medium increased linearly for about 48 hr.
Launched in more than 40 countries for multiple indications, Synacthen (tetracosactide) is a synthetic 24 amino acid melanocortin receptor agonist.