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a toxin treated by heat or chemical agent to destroy its deleterious properties without destroying its ability to combine with or stimulate the formation of antitoxin.
diphtheria toxoid a sterile preparation of formaldehyde-treated products of the growth of Corynebacterium diphtheriae, used as an active immunizing agent, generally in mixtures with tetanus toxoid and pertussis vaccine (DTP) or with tetanus toxoid alone (DT for pediatric use and Td, which contains less diphtheria toxoid, for adult use).
tetanus toxoid a sterile preparation of formaldehyde-treated products of the growth of Clostridium tetani, used as an active immunizing agent, either in mixtures with diphtheria toxoid and pertussis vaccine (DTP, DT, Td) or by itself (T).
an active immunizing agent prepared from detoxified tetanus toxin that produces an antigenic response in the body, conferring permanent immunity to tetanus infection.
indications It is prescribed for primary active immunization against tetanus, generally in combination with diphtheria and pertussis vaccines.
contraindications Immunosuppression or immunoglobulin abnormalities, acute infection, or illness prohibits its use.
adverse effects The most serious adverse effect is hypersensitivity. Pain and inflammation at the site of injection may occur.
tetanus toxoidA small peptide fragment that selectively elicits helper immune response but not immune suppression
Tetanus toxoid is a vaccine used to prevent tetanus (also known as lockjaw).
Mentioned in: Clenched Fist Injury
tetanus toxoid (tetˑ·ns täkˑ·soid),
n detoxified tetanus poison used to produce a permanent immune response against tetanus infections. See also tetanus vaccine.
a highly fatal disease of all animal species caused by the neurotoxin of Clostridium tetani. The bacterial spores are deposited in tissue, usually by traumatic injury, retained placenta or endometrial injury and under anaerobic conditions vegetate. Clinical features of the disease are remarkably similar in all species but there are differences in susceptibility to the disease. The muscle spasms cause a stiff gait, rigid posture (sometimes called 'sawhorse stance'), extension or elevation of the tail, protrusion of the third eyelid and trismus (lockjaw). Horses show flaring of the nostrils. In dogs, spasms of facial muscles cause abnormally erect ears and retraction of the lips that resembles the 'risus sardonicus' seen in humans with tetanus. Stimulation precipitates generalized muscle contractions and tetanic spasms or convulsions. The disease can be prevented by immunization with tetanus toxoid or the use of antitoxin, but this is done routinely only in humans and horses.
see tetanus antitoxin.
a loosely defined syndrome of outbreaks of tetanus in young cattle without a wound being found; current practice is to refer to such outbreaks as being caused by the ingestion of pre-formed tetanus toxin.
tetany occurs predominantly in one limb, closest to the site of entry of the organism, but then usually spreads to the opposite limb and then the whole body. Seen in dogs and particularly cats.
see tetanus toxin.