tetanospasmin


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tetanospasmin

 [tet″ah-no-spaz´min]
the neurotoxic component of the tetanus toxin, which causes the muscle spasms of tetanus.

tet·a·no·spas·min

(tet'ă-nō-spaz'min),
The neurotoxin of Clostridium tetani, which causes the characteristic signs and symptoms of tetanus; chief action is on the anterior horn cells, and the spasms seem to be due to action at inhibitory synapses.

tetanospasmin

Toxicology A 150 kD neurotoxin produced by Clostridium tetani, which is one of the most toxic substances known to man; it selectively blocks inhibitory nerve transmission from the spinal cord to the muscles, causing severe muscle spasms, which may be intense enough to tear muscle or cause compression fractures of the vertebrae; it evokes unrestrained muscle firing and sustained muscular contraction, causing lockjaw, dysphagia, or acute respiratory failure by tetany of the diaphragm. See Poisons.

tet·a·no·spas·min

(tet'ă-nō-spaz'min)
The neurotoxin of Clostridium tetani, which causes the characteristic signs and symptoms of tetanus; chief action is on the anterior horn cells, and the spasms seem to be due to action at inhibitory synapses.
References in periodicals archive ?
Several theories have been proposed, including damage to brain stem and hypothalamic nuclei, and direct disturbances in autonomic nerves (by tetanospasmin).
[9,10] Tetanospasmin blocks the inhibitory transmitter release from the presynaptic terminal of inhibitory spinal interneurons, resulting in sympathetic overdrive.
In severe cases the release of tetanolysin and tetanospasmin can lead to respiratory failure and hemodynamic instability associated with dysautonomia.
tetani in which clinical signs of tetanus did not develop despite production of tetanospasmin by the infecting strain.
The case reported here is remarkable because clinical tetanus did not develop despite the production of tetanospasmin by the infecting strain and because late relapse occurred despite adapted treatment.
The tetanospasmin toxin is produced during cell growth and released upon cell lysis (occurs during vegetative growth and the production of endospores).
tetani colonizes devitalized tissue, the exotoxin tetanospasmin is disseminated to inhibitory motor neurons, resulting in tetanus.
While two toxins, tetanospasmin and tetanolysin, are produced, tetanospasmin is responsible for manifestations of the disease.
Tetanus is an acute, potentially fatal disease caused by Clostridium Tetani which produces a powerful neurotoxin tetanospasmin which affects the central nervous system.1 Although tetanus is almost entirely preventable through immunization, the burden of disease is large world wide.
Tetanus is caused by tetanospasmin, an exotoxin produced by Clostridium tetani spores, which are ubiquitous in the environment and enter the body usually through a wound; proliferation of bacilli under anaerobic conditions results in the production of tetanospasmin.
The condition is characterized by increased muscle tone and spasmodic contractions due to Tetanospasmin, a powerful exotoxin produced by Clostridium tetani, a ubiquitous obligate anaerobic gram positive organism.