tetanospasmin


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tetanospasmin

 [tet″ah-no-spaz´min]
the neurotoxic component of the tetanus toxin, which causes the muscle spasms of tetanus.

tet·a·no·spas·min

(tet'ă-nō-spaz'min),
The neurotoxin of Clostridium tetani, which causes the characteristic signs and symptoms of tetanus; chief action is on the anterior horn cells, and the spasms seem to be due to action at inhibitory synapses.

tetanospasmin

/tet·a·no·spas·min/ (tet″ah-no-spaz´min) the neurotoxic component of the exotoxin (tetanus toxin) produced by Clostridium tetani, which causes the typical muscle spasms of tetanus.

tetanospasmin

Toxicology A 150 kD neurotoxin produced by Clostridium tetani, which is one of the most toxic substances known to man; it selectively blocks inhibitory nerve transmission from the spinal cord to the muscles, causing severe muscle spasms, which may be intense enough to tear muscle or cause compression fractures of the vertebrae; it evokes unrestrained muscle firing and sustained muscular contraction, causing lockjaw, dysphagia, or acute respiratory failure by tetany of the diaphragm. See Poisons.

tet·a·no·spas·min

(tet'ă-nō-spaz'min)
The neurotoxin of Clostridium tetani, which causes the characteristic signs and symptoms of tetanus; chief action is on the anterior horn cells, and the spasms seem to be due to action at inhibitory synapses.

tetanospasmin

the neurotoxic exotoxin produced by Clostridium tetani, which inhibits release of gamma amino butyric acid by inhibitory neurons, resulting in tetanic spasms.
References in periodicals archive ?
9,10] Tetanospasmin blocks the inhibitory transmitter release from the presynaptic terminal of inhibitory spinal interneurons, resulting in sympathetic overdrive.
Tetanospasmin is a neurotoxin--It is 150 kd simple protein consisting of heavy chain and light joined by single disulfide bond.
tetani in which clinical signs of tetanus did not develop despite production of tetanospasmin by the infecting strain.
The case reported here is remarkable because clinical tetanus did not develop despite the production of tetanospasmin by the infecting strain and because late relapse occurred despite adapted treatment.
The tetanospasmin toxin is produced during cell growth and released upon cell lysis (occurs during vegetative growth and the production of endospores).
While two toxins, tetanospasmin and tetanolysin, are produced, tetanospasmin is responsible for manifestations of the disease.
The condition is characterized by increased muscle tone and spasmodic contractions due to Tetanospasmin, a powerful exotoxin produced by Clostridium tetani, a ubiquitous obligate anaerobic gram positive organism.
Tetanospasmin is formed in the vegetative cells, under plasmid control that interferes with the inhibitory neurotransmitters, causing the trismus.
Tetanus is caused by tetanospasmin, an exotoxin produced by Clostridium tetani spores, which are ubiquitous in the environment and enter the body usually through a wound; proliferation of bacilli under anaerobic conditions results in the production of tetanospasmin.