testosterone replacement therapy


Also found in: Acronyms.

androgen replacement therapy

The administration of androgens (e.g., testosterone or its congeners) in men with hypogonadal androgen-deficiency, which may be primary or secondary and either congenital or acquired. The intent of ART is to restore normal physiologic effects of testosterone, which depend on the stage of sexual development.

In androgen-deficient boys, the goal of ART is to initiate and maintain androgen-dependent activities, including somatic development (e.g., development of skeletal muscle and increased strength, long bone growth, redistribution of body fat and erythropoiesis), sexual behaviour (increased libido and potency) and development of 2º sexual characteristics (e.g., male pattern of hair growth, penile and scrotal enlargement, laryngeal enlargement and thickening of the vocal cords, and deepening of the voice).

Androgen replacement therapies 
Oral
Pros
Convenience.
 
Cons
The oral testosterones available in the US are methyl testosterone and fluoxymesterone; both are nonphysiological, 17-alkylated molecules with hepatotoxic potential.
 
Transdermal
Pros
Well-absorbed physiologic testosterone.

Cons
Inconvenience of shaving scrotal skin; impregnation of patches with absorption enhancers, such as alcohol, allows their application to nongenital skin, but causes local irritation in up to 53% of patients.
 
Injectable
Pros
Absorbed physiologic testosterone.

Cons
Painful.

Sublingual AndroTest-SL®
Pros
Convenience; physiologic testosterone.

Cons
None.

testosterone replacement therapy

Androgen replacement therapy, see there.
References in periodicals archive ?
That's what most of us in the field have believed, that there is a reduction in cardiac events with testosterone replacement therapy," Dr.
3) In one study, men who did not have documented hypogonadism received testosterone replacement therapy for sexual dysfunction including ED or ejaculator dysfunction.
Used appropriately, and with regular blood tests, testosterone replacement therapy can reverse many of these age-related disorders.
The statement challenges several aspects of a recent Food and Drug Administration safety announcement warning about "possible" increased risks of heart attack and stroke with testosterone replacement therapy (TRT) and approving its use only for testicular, pituitary, or brain disorders that cause low testosterone, not for age-associated hypogonadism.
If the baseline hematocrit is more than 47%, consider alternative treatments, but proceed if testosterone replacement therapy seems to be the best clinical option.
But when testosterone replacement therapy was added to their regimen, the control spiked to 87.
A Small-scale Clinical Trial to Determine the Safety and Efficacy of Testosterone Replacement Therapy in Hypogonadal Men with Spinal Cord Injury.
On one hand, low testosterone levels have been linked to heart disease, leading enthusiasts to recommend testosterone replacement therapy.
They suggested trials should be carried out into whether testosterone replacement therapy would benefit this group.
Until recently, doctors seldom prescribed testosterone replacement therapy because of worries that the hormone would promote prostate cancer.