testosterone replacement therapy


Also found in: Acronyms.

androgen replacement therapy

The administration of androgens (e.g., testosterone or its congeners) in men with hypogonadal androgen-deficiency, which may be primary or secondary and either congenital or acquired. The intent of ART is to restore normal physiologic effects of testosterone, which depend on the stage of sexual development.

In androgen-deficient boys, the goal of ART is to initiate and maintain androgen-dependent activities, including somatic development (e.g., development of skeletal muscle and increased strength, long bone growth, redistribution of body fat and erythropoiesis), sexual behaviour (increased libido and potency) and development of 2º sexual characteristics (e.g., male pattern of hair growth, penile and scrotal enlargement, laryngeal enlargement and thickening of the vocal cords, and deepening of the voice).

Androgen replacement therapies 
Oral
Pros
Convenience.
 
Cons
The oral testosterones available in the US are methyl testosterone and fluoxymesterone; both are nonphysiological, 17-alkylated molecules with hepatotoxic potential.
 
Transdermal
Pros
Well-absorbed physiologic testosterone.

Cons
Inconvenience of shaving scrotal skin; impregnation of patches with absorption enhancers, such as alcohol, allows their application to nongenital skin, but causes local irritation in up to 53% of patients.
 
Injectable
Pros
Absorbed physiologic testosterone.

Cons
Painful.

Sublingual AndroTest-SL®
Pros
Convenience; physiologic testosterone.

Cons
None.

testosterone replacement therapy

Androgen replacement therapy, see there.
References in periodicals archive ?
"The question of whether to use testosterone replacement therapy in men with COPD is highly controversial.
The researchers also broke down stone events by type of testosterone replacement therapy. A total of 5.4% of patients who received pellets (9 of 167) experienced an event (P = .27), compared with 5.1% of those who received injections (218 of 4,259; P = .004) and 3.5% of those who received it topically (655 of 18,895; P less than .0001).
In our patient, testosterone replacement therapy had been terminated at the age of 19, after he responded well in terms of growth and development of secondary male sexual characteristics.
(3) In one study, men who did not have documented hypogonadism received testosterone replacement therapy for sexual dysfunction including ED or ejaculator dysfunction.
With a wealth of studies showing positive benefits, and in the face of the FDA's irrational decision based on flawed studies, it is time to review the good science on this issue, and to make balanced recommendations about testosterone replacement therapy.
It is likely that as our understanding of testosterone replacement therapy improves, there will be an increased interest in clinical testing for this metabolite of testosterone.
Geriatric Grab Bag: ED, Testosterone Replacement Therapy and BPH
NEW ORLEANSE--Evidence seems to be mounting that the link between testosterone replacement therapy and increased hematocrit doesn't lead to more cardiac or thrombotic events in men.
Former UFC light heavyweight champion Vitor Belfort thinks he is a better fighter without the testosterone replacement therapy (TRT) that he has been undergoing the past couple of months.
The political climate is working against testosterone replacement therapy in older men despite overwhelming scientific data supporting this appropriate pursuit as a strategy to prolong healthy longevity." (11)